Intrinsic hearing protection mechanisms: a pathway to prevention of noise-induced hearing loss

噪声性听力损失(NIHL)是造成疾病总负担的重要因素。我们最近确定，当耳朵暴露在持续的噪声中时，耳蜗会通过激活特定的(P2X2)受体而受到保护，这显然是可逆的听力适应。这项研究将确定该受体的下游信号。这将支持对非霍奇金淋巴瘤易感性的评估，并有助于听力疗法的发展。

Noise-induced hearing loss (NIHL) is a significant contributor to the total burden of disease. We recently determined that when the ear is exposed to sustained noise, the cochlea is protected from damage by activation of a specific (P2X2) receptor, evident as reversible hearing adaptation. This study will determine the downstream signalling from this receptor. This will support assessment of vulnerability to NIHL and contribute to development of hearing therapeutics.