Core D: Analytic Core

烟草烟雾是一种非常复杂的样品，含有多达4800种单独的物质（Hoffmann， Hoffmann等人，2001年，Baker， Bishop 2004年，Thielena， Klusb等人，2008年）。这些物质的挥发性在很大范围内随浓度变化而变化。有些物质是烟草的添加剂，但大多数是烟草的天然成分（如纤维素）热解/燃烧的产物。相对较高的温度（~ 950°C）允许复杂的反应发生，产生非常多样化的化合物。然而，几乎三分之二的添加剂会发生<5%的分解或反应（Baker, Bishop 2004）。化合物分布在气相和颗粒相（液体气溶胶）之间。对于有机化合物，大约75%处于颗粒相，25%处于气相。对粒子取样是一项非常具有挑战性的任务。通常，颗粒是通过过滤器收集的，

Tobacco smoke is a very complex sample, containing upwards of 4800 individual substances (Hoffmann, Hoffmann et al. 2001, Baker, Bishop 2004, Thielena, Klusb et al. 2008). The volatility of these substances vanes over a large range as does the concentration. Some of the substances are additives to the tobacco, but most are products of pyrolysis/combustion of natural components of tobacco, e.g. cellulose. The relatively high temperature (~ 950 °C) allows complex reactions to occur, generating a very diverse collection of compounds. However, almost two-thirds of additives undergo <5% decomposition or reaction (Baker, Bishop 2004). The compounds are distributed between the gas phase are particle phase (liquid aerosol). For organic compounds, about 75% are in the particle phase and 25% in the gas phase. Sampling the particles is a very challenging task. Typically particles are collected on filters, extracted (and sometimes derivatized), and then analyzed by GC/MS or LC/MS (Figure 1). It has been known for some time that artifacts can be produced in this procedure. We have confirmed this using the setup shown in Figure 1. Research in our lab has recently been focused on developing new approaches to reduce or eliminate collection/extraction steps in the analysis of smoke, to minimize artifact formation.