Pediatric Pathology Translational Research

描述(由申请人提供)：这是Ruth L.Kirschstein机构国家研究服务奖(NRSA/T32)的修订申请，为医学博士、医学博士/博士和博士研究员准备在转化性儿科病理学研究中作为独立研究员的博士后研究培训而开发。有一个特别的重点是研究 研究儿童特别常见的心、肺或血液疾病的病理生理学。该计划建议包括在转化医学、人类受试者研究、研究的伦理行为、基因组学和蛋白质组学等创新技术方面的正式教学培训，以及在由波士顿儿童医院和哈佛大学催化剂临床翻译科学中心(CTSC)提供的大量教育和职业发展资源支持的学术丰富环境中的指导研究经验。该培训计划以波士顿儿童医院病理科为中心，其研究人员得到了波士顿儿童医院、布里格姆妇女医院、哈佛医学院和布罗德研究所其他科室的翻译调查人员的支持。为了加强课程的协作性和转化性，受训者还需要借鉴儿科临床病理学系的经验，并鼓励他们利用系内大量冰冻和福尔马林固定、石蜡包埋的组织资源进行研究。最重要的是，该计划的首要目标是赋予下一代转化型儿科病理学家技能，为儿科疾病的创新诊断和治疗做出贡献。

DESCRIPTION (provided by applicant): This is a revised application for a Ruth L. Kirschstein Institutional National Research Service Award (NRSA/T32) developed for post-doctoral research training for MD, MD/PhD, and PhD fellows preparing for a career as an independent investigator in translational pediatric pathology research. There is a particular focus on research into the pathophysiology of disorders of the heart, lung or blood that are particularly prevalent i children. The Program proposal includes formal didactic training in translational medicine, human subjects research, the ethical conduct of research, and innovative technologies such as genomics and proteomics as well as a mentored research experience in an academically rich environment that is supported by numerous educational and career development resources provided by Children's Hospital Boston and the Harvard Catalyst Clinical Translational Sciences Center (CTSC). The Training Program centers around the Department of Pathology at Children's Hospital Boston and involves its research faculty supported by a select group of translational investigators from other Departments at Children's Hospital Boston, the Brigham and Women's Hospital, Harvard Medical School, and the Broad Institute. To enhance the collaborative, translational pathology nature of the Program, trainees are also required to draw upon the experience of the clinical pediatric pathology faculty and are encouraged to utilize the substantial frozen and formalin-fixed, paraffin-embedded tissue resources of the Department for their studies. Above all, the overriding goal of the Program is to endow the next generation of translational pediatric pathologists with the skills to contribute to innovative diagnostics and treatment of pediatric diseases.