Core 3: Pilot p342-353

试点核心的目标是激发耶鲁烟草中心内外的研究， 监管科学（TCORS），并允许调查人员开发初步证据， 提交极具竞争力的校外资助申请。耶鲁大学的四个研究组成部分 TCORS的重点是了解烟草添加剂的作用和修改的风险烟草产品， 涉及人类的行为、分子、药理学、流行病学和经济科学（ 临床、经济和流行病学研究）和动物（基础研究）。试点项目供资的项目 核心将反映和补充这些目标。试点核心将负责审查、资助和 每年监督多达5个TCORS试点项目，这些项目与耶鲁TCORS的目标相关， 减少对烟草制品的成瘾，其他TCORS网站的目标，以及监管需求 FDA的。此外，与实验室和行政核心一起，试点核心将促进 在教育和培训中心培训初级调查员，为他们提供资金， 与烟草监管科学相关的独立研究项目。 耶鲁大学参与这项拟议TCORS的研究人员在进行TCORS方面有着悠久的历史 烟草使用的多学科研究计划。从2000年到2011年，我们领导了一项NIH跨学科研究， 烟草使用研究中心（TTURC）专注于烟草依赖和治疗失败的风险因素 以便最终开发出新的治疗方法。作为这项工作的一部分，我们成功地征求和 审查了试点项目，并支持为33个试点项目提供资金。资助了52篇出版物和14篇NIH论文 这些试点项目产生了赠款。此外，《技术转让使用报告准则》及其试点机制促成了 耶鲁大学烟草使用研究中心（世纪）的凝聚力，一个超过25人的核心小组， 专注于烟草研究的教师（世纪网站：http://centurv.vale.edu），并进一步 刺激了耶鲁大学社区内外的烟草研究和合作。因此，我们以前的 经验表明，我们有能力成功地完成拟议的活动。

The goal of the Pilot Core is to galvanize research within and outside the Yale Tobacco Center of Regulatory Science (TCORS) and to allow investigators to develop preliminary evidence that would enable submission of highly competitive extramural funding applications. The 4 research components of the Yale TCORS focus on understanding the role of tobacco additives and modified risk tobacco products through behavioral, molecular, pharmacological, epidemiological, and economic sciences that involve humans (in clinical, economic, and epidemiological research) and animals (basic research). Projects funded by the Pilot Core will reflect and complement these goals. The Pilot Core will be responsible for review, funding, and oversight of up to 5 TCORS pilot projects per year that are relevant to the goals of the Yale TCORS of reducing the addiction to tobacco products, to the goals of the other TCORS sites, and to the regulatory needs ofthe FDA. Further, in conjunction with the Laboratory and Administrative Cores, the Pilot Core will facilitate the training of junior investigators in the Education and Training Core by providing them with funds to initiate independent research projects that are relevant to tobacco regulatory science. Researchers involved in this proposed TCORS at Yale University have an established history of conducting programs of multidisciplinary research in tobacco use. From 2000-2011, we led an NIH Transdisciplinary Tobacco Use Research Center (TTURC) focused on tobacco dependence and risk factors for treatment failure in order to ultimately develop new approaches for treatment. As part of this effort we successfully solicited and reviewed pilot projects, and supported funding for 33 pilot projects. Fifty-two publications and 14 NIH funded grants resulted from these pilots. Moreover, the TTURC and its pilot mechanism led to the creation and cohesiveness of the Center for Tobacco Use Research at Yale (CENTURY), a core group of more than 25 faculty members who focus on tobacco research (CENTURY website: http://centurv.vale.edu) and has further stimulated tobacco research and collaborations within and outside the Yale community. Thus, our previous experience demonstrates our ability to successfully accomplish the proposed activities.