DTS Imaging with a Digitally Addressable X-Ray Source (DAXS)

描述（由申请人提供）：DTS成像与数字可寻位x射线源（DAXS）摘要4-D x射线成像将为涉及造影剂注射或解剖运动的成像程序提供强大的工具。在这项研究中，我们建议开发和研究基于数字断层合成（DTS）和数字可寻址x射线源（DAXS）的4-D x射线成像系统。DAXS允许在平面x射线面板上的任何数字选择位置生成x射线。这将使我们能够设计和构建一个不包含移动部件的固定DTS系统。由于消除了物理运动部件，扫描速度可以大大提高，从而允许4-D成像，可以成像和监测运动解剖或注射造影剂的3-D图像。DAXS的使用还允许x射线源以二维模式进行数字移位，从而更有效地模糊焦平面外的物体，并提高平面内物体的对比度。拟议的研究由两个主要部分组成，分别在两个不同的地点进行：位于德克萨斯州奥斯汀的恒星微设备公司（SMD）的子公司Stellarray公司和位于德克萨斯州休斯顿的德州大学安德森癌症中心（MDACC）的数字成像研究实验室（DIRL）。这两个地点的密切关系鼓励了积极的合作和互动。在这次学术-工业合作中，DAXS技术将在SMD开发，并提供给MDACC-DIRL，以实施和研究DTS技术用于4-D成像。操作参数和图像质量指标将被调查和优化。幻影实验将进行演示和验证所提出的4-D x射线成像技术。在这次合作中，每个站点将有一个单独的首席研究员（PI）。MDACC的PI也将作为联络和协调PI。

DESCRIPTION (provided by applicant): DTS imaging with a Digitally Addressable X-ray Source (DAXS) Abstract 4-D x-ray imaging would provide a powerful tool for imaging procedures involving contrast injection or anatomical motions. In this research, we propose to develop and investigate a 4-D x-ray imaging system based on digital tomosynthesis (DTS) and a digitally addressable x-ray source (DAXS). The DAXS allows x-rays to be generated at any digitally selected location on a flat x-ray panel. This would enable us to design and construct a stationary DTS system that contains no moving parts. Due to the elimination of physically moving parts, the scan speed can be substantially increased, thus allowing for 4-D imaging, with which 3-D images of moving anatomy or injected contrast materials can be imaged and monitored. The use of a DAXS also allows the x-ray source to be digitally shifted with a 2-D pattern, leading to more effective blurring of the out of focal plane objects and better contrast of the in plane objects. The proposed research consists of two major parts carried out at two different sites: Stellarray Inc., a subsidiary of Stellar Micro Devices, Inc. (SMD) at Austin, TX and the Digital Imaging Research Laboratory (DIRL) at the U. of Texas M. D. Anderson Cancer Center (MDACC) at Houston, TX. The closeness of the two sites encourages active collaboration and interaction. In this Academic-Industry collaboration, the DAXS technology will be developed at SMD and provided to MDACC-DIRL to implement and investigate the DTS techniques for 4-D imaging. Operation parameters and image quality metrics will be investigated and optimized. Phantom experiments will be performed to demonstrate and validate the proposed 4-D x-ray imaging techniques. In this collaboration, there will be a separate Principal Investigator (PI) at each site. The MDACC PI will also serve as the contact and coordinating PI.