Workshops On Viral Oncogenesis and Pathogenesis

要求提供资金，以继续每年举行一系列关于癌症病毒学跨学科问题的会议。癌症病毒一直是科学研究的重要对象，因为1）它们提供了对基本癌症过程的许多见解，以及2）癌症病毒是癌症的主要病原体。全世界20-25%的癌症有病毒病因。虽然有几个专业会议涉及特定致癌病毒的生物化学和分子生物学，但没有其他会议以跨学科的方式处理所有这些病毒。在竞争更新的第一次会议上，我们提出了“与人类癌症相关的新病毒”的主题。最近已经鉴定了用于人类癌症的新的候选病毒，最值得注意的是默克尔细胞癌中的MCPyV和前列腺癌中的XMRV;还鉴定了用于其他人类癌症的其他候选病毒。本次会议将汇集这些新病毒的研究人员与那些致力于建立人类致癌病毒，包括疱疹病毒（EBV，KSHV），乳头瘤病毒（HPV），逆转录病毒（HTLV-I）和肝炎病毒（HBV和HCV）的研究人员。一个跨学科的会议将是有价值的，因为不同的致癌病毒使用不同的致癌转化机制（直接和间接），这将提供重要的概念框架，为新的候选人人类致癌病毒。会议在随后几年将解决的主题，如病毒和细胞内运输，病毒癌基因，病毒潜伏期和持久性，和转录后调节病毒表达。

Funds are requested to continue an annual series of meetings on interdisciplinary aspects of cancer virology. Cancer viruses have been important subjects for scientific study, since 1) they have provided numerous insights into basic cancer processes, and 2) ca. 20-25% of cancer worldwide has a viral etiology. While there are several specialty meetings that deal with the biochemistry and molecular biology of particular oncogenic viruses, there are no other meetings that deal with all of these viruses in an interdisciplinary fashion. For the first meeting in the competing renewal, we propose the topic of "New Viruses Associated with Human Cancer". Recently new candidate viruses for human cancers have been identified, most notably MCPyV in Merkel cell carcinoma and XMRV in prostate cancer; additional candidate viruses for other human cancers also have been identified. This meeting will bring together researchers on these new viruses with those working on established human oncogenic viruses including herpesviruses (EBV, KSHV), papillomaviruses (HPV), retroviruses (HTLV-I), and hepatitis viruses (HBV and HCV). An interdisciplinary meeting will be valuable since different oncogenic viruses use different mechanisms in oncogenic transformation (direct and indirect), which will provide important conceptual frameworks for the new candidate human oncogenic viruses. Meetings in subsequent years will address topics such as Viruses and Intracellular Trafficking, Viral Oncogenes, Viral Latency and Persistence, and Post-transcriptional Regulation of Viral Expression.