Signaling Pathways in Innate Immunity

描述（由申请人提供）：在过去的15年里，现代免疫学在先天免疫领域发生了前所未有的知识扩张。“先天免疫信号通路”（SPII）培训计划代表了一个修订的，新的T32申请，以支持这一重要和新兴领域的2名博士前和2名博士后学员。马里兰大学医学院（UMSOM）在这一领域具有重要的研究和培训优势。这个独特而高度集中的项目的培训资助教师（TGF）主要来自UMSOM的微生物学和免疫学系以及几个跨学科中心和研究所，包括粘膜生物学研究中心、血管和炎症疾病中心、疫苗开发中心、Greenebaum癌症中心和人类病毒学研究所。除了一家外，所有的TGF都位于UMSOM校园微生物与免疫学系的2个街区范围内。TGF在资助和出版方面有着悠久的合作历史，并且资金充足，每年的资助和合同直接成本总计约为1740万美元。博士预科学员将主要从跨部门的生命科学研究生项目（GPILS）、分子微生物学与免疫学（MMI）和分子医学（MM）项目、已建立的博士项目（包括共同核心课程、项目特定课程、选修课程、期刊俱乐部、研讨会、年度专题讨论会和研究生研究报告日）中抽取。额外的学术工作将与严格的实验室训练相结合，通过实验室轮转和论文研究在TGF的指导下，其记录的专业知识将提供跨学科和多学科的培训机会。预科生是从越来越多的合格申请者中挑选出来的，也从UMSOM的医学博士/博士中挑选出来。程序。同样，我们的培训基金合格的博士后学员越来越多地被吸引到具有先天免疫信号专业知识的实验室。pre- and - postdoctoral受训者都将有额外的教学和非教学要求，包括负责任的研究行为和专业发展方面的培训，以及高度结构化的指导计划。已经作出具体努力，从代表性不足的少数民族中招募受训人员。该计划由一支高素质的团队指导，包括培训计划主任、两名联合主任、一个指导委员会和一个由国际公认的先天免疫专家组成的外部咨询委员会。我们预计我们的学员将会非常好

DESCRIPTION (provided by applicant): An unprecedented expansion of knowledge has occurred in modern immunology in the field of innate immunity over the last 15 years. The "Signaling Pathways in Innate Immunity" (SPII) Training Program represents a revised, new T32 application to support 2 predoctoral and 2 postdoctoral trainees in this important and burgeoning area. The University of Maryland, School of Medicine (UMSOM) has significant research and training strengths in this area. The Training Grant Faculty (TGF) for this unique and highly focused program are drawn primarily from the Department of Microbiology and Immunology and several interdisciplinary centers and institutes at UMSOM including the Mucosal Biology Research Center, the Center for Vascular and Inflammatory Diseases, the Center for Vaccine Development, Greenebaum Cancer Center, and the Institute of Human Virology. All but one TGF are located within a 2-block distance of the Department of Microbiology & Immunology on the UMSOM campus. The TGF have a longstanding history of collaboration on grants and publications, and are well funded, with grants and contracts totaling ~$17.4 million in annual direct costs. Predoctoral trainees will be drawn primarily from the interdepartmental Graduate Program in Life Sciences (GPILS) Programs in Molecular Microbiology & Immunology (MMI) and Molecular Medicine (MM), established Ph.D. Programs that include a common core curriculum, program-specific courses, elective courses, journal clubs, seminars, annual symposia, and graduate research presentation days. Additional academic work will be combined with rigorous laboratory training through laboratory rotations and dissertation research under the direction of the TGF whose documented expertise will provide inter- and multidisciplinary training opportunities. Predoctoral students are selected from an increasingly qualified applicant pool, as well as from the UMSOM M.D./Ph.D. Program. Similarly, our Training Grant Eligible postdoctoral trainees are increasingly gravitating to laboratories with expertise in innate immune signaling. Both pre- and postdoctoral trainees will have additional didactic and non-didactic requirements, including training in the responsible conduct of research and professional development, as well as a highly structured mentoring program. Specific efforts are already in place to recruit trainees from underrepresented minorities. The program is guided by a highly qualified team including the Training Program Director, two Co-Directors, a Steering Committee, and an External Advisory Committee comprised of internationally recognized experts in innate immunity. We anticipate that our trainees will be extraordinarily well prepared for future careers in academia, government, and industry and will contribute in significant ways to basic and translational problems in this complex area of innate immunity.