Project 2: Fate and Effects of Inhaled ENMs in the Lung

纳米材料吸入暴露和潜在的健康影响 工程纳米材料（ENM）是一种新兴的材料类别，正在越来越多地使用 在成像，电子和治疗领域;然而，它们已经是越来越多的 这些产品通常用于电脑芯片、化妆品、服装和膳食补充剂。甚至 尽管这些环境管理措施可能被证明是有益的，但人们对它们的潜力表示担忧 健康风险。虽然这些粒子在过去几十年中一直在研究，但直到最近才开始研究。 ENMs的潜在毒性已经被认真研究。这个毒性问题最近被 7名工厂女工在工作期间暴露于纳米颗粒5-13年的病例报告突出了这一点 患有肺纤维化和炎症的肺损伤的人，尽管可能有 这些不幸事件中还有其他因素。 可能接触到ENM的人包括工人、消费者和公众， 许多途径，包括通过皮肤或通过胃肠道途径或通过眼睛，但吸入途径 仍然可能是最重要的一个。吸入途径也是一个重要的一个， ENM的应用，包括成像剂、基因治疗和向感染者或患者的治疗药物递送。 肿瘤部位。

Nanomaterial Inhalational Exposure and Potential Health Effects Engineered nanomaterials (ENMs) are an emerging category of materials that are finding increasing use in the areas of imaging, electronics and therapeutics; however, they are already part of a widening number of products that are commonly used such as computer chips, cosmetics, clothing and dietary supplements. Even though these ENMs may prove to be beneficial, there have been concerns raised regarding their potential health risks. Although these particles have been studied for the last few decades, only recently has the potential toxicity of ENMs been researched in a serious way. This issue of toxicity has been recently highlighted by the case report of 7 female factory workers exposed to nanoparticles during their work for 5-13 months who developed lung damage with pulmonary fibrosis and inflammation^, although there may have been other factors involved in these unfortunate cases. People that may be exposed to ENMs include workers, consumers and the general public through a number of ways that include by skin or by the gastrointestinal route or through the eyes, but the inhaled route remains potentially the most important one. The inhaled route is also an important one for a number of applicafions for ENMs including imaging agents, gene therapy and therapeufic drug delivery to infected or tumour sites.