Novel Neuromodulatory Intervention in the Rehabilitation of Pediatric Hemiparesis

描述(由申请者提供)：该项目旨在培养独立的Bernadette Gillick，博士，MSPT，PT作为康复科学家，并促进神经缺陷儿童的康复研究。吉利克博士是一位正在发展中的康复科学家 拥有20多年的临床经验；对神经损伤后发育中的大脑的重组以及电生理和行为干预对神经康复的影响都有研究兴趣。吉利克博士的职业发展目标包括扩大她在进行临床试验方面的知识，掌握研究大脑重组的技术，以及创造旨在促进功能运动恢复的新干预措施。自上次提交报告以来，吉利克博士重新组建了一个全面的导师团队和一个研究顾问委员会，以指导和指导她的培训。培训计划包括与导师的正式会议，临床研究证书授课培训，全国会议演示，准备拨款申请和手稿。该研究项目将吉利克博士的工作带向了一个尚未被研究的方向--在儿科康复中使用一种新型的非侵入性脑刺激。通过她以前的经验，她了解到电生理和行为干预可以产生有益的协同效应。她最近还完成了一项使用新型非侵入性脑刺激的安全试验。基于这些有希望的发现，吉利克博士建议将干预措施与更彻底地了解其效果的干预措施结合起来，这些干预措施可以方便地到达临床环境，而且成本更低。这种新的康复方法的整合可能会导致个人一生中运动功能的改善。Gillick博士的K01职业发展培训和研究提供的高级支持将通过培养一名能够在儿科神经康复方面进行临床相关和转化性研究的独立科学家来为NIH做出贡献。

DESCRIPTION (provided by applicant): This project is designed to train to independence Bernadette Gillick, PhD, MSPT, PT as a rehabilitation scientist and to advance rehabilitation research in children with neurologic deficits. Dr. Gillick is a developing rehabilitation scientist with over two decades of clinical experience; with research interest both in the reorganization of the developing brain after neurologic insult or injury, and in the influence of electrophysiologic and behavioral interventions on neurorecovery. Dr. Gillick's career development objectives include expanding her knowledge of running clinical trials, mastering techniques to investigate brain reorganization and creating novel interventions designed to enhance functional motor recovery. Since last submission, Dr. Gillick has reassembled a comprehensive team of mentors and a research advisory committee to direct and guide her training. The training plan includes formal meetings with mentors, didactic training with a Certificate in Clinical Research, national meeting presentations, preparation of grant applications and manuscripts. The research project takes Dr. Gillick's work in a direction not yet studied-the use of a novel form of non-invasive brain stimulation in pediatric rehabilitation. Through her prior experience, she has learned that electrophysiologic and behavioral interventions can have a beneficial synergistic effect. She has also recently completed a safety pilot in the use of a novel form of non-invasive brain stimulation. Based on these promising findings Dr. Gillick proposes to combine interventions that, with a more thorough understanding of their effects, can conveniently reach the clinical setting and will cost less. The integration of this novel rehabilitation approach may lead to improved motor function for individuals throughout their lifetimes. The advanced support provided by the K01 career development training and research of Dr. Gillick will contribute to the NIH by producing an independent scientist able to conduct clinically relevant and translational research in pediatric neurorecovery.