P30 Wilmer Core Grant for Vision Research

描述(申请人提供)：威尔默眼科研究所是视觉研究的世界领先者之一。它的研究项目范围从眼睛发育和视力机制的基础/基础研究，到眼部疾病的遗传学和发病机制研究，到过渡性研究，到临床试验，再到世界范围内导致视力丧失和残疾的流行病学和国际研究。Wilmer有幸通过NEI视觉研究核心助学金获得了超过35年的资金，这笔资金为各种此类研究提供了基础设施和核心支持。核心基金提供的支持对促进威尔默的多样化研究项目起到了巨大的帮助作用，它还鼓励了许多合作研究项目。在这次竞争性续签申请中，我们正在寻求支持，以继续这些基本的基础设施和核心活动。我们建议既继续过去的服务，又修改和重新定向一些核心，以便更好地适应不断变化的研究需求、技术和优先事项。申请资助的模块是成像和显微镜、生物统计学、生物信息学、动物建模的核心，以及药物输送和纳米技术的新模块。我们认为，这种新的模块结构，加上严格的行政支持结构，将最好地为威尔默和整个霍普金斯大学多样化的愿景研究活动提供服务和便利。

DESCRIPTION (provided by applicant): The Wilmer Eye Institute is one of the world leaders in vision research. Its research programs range from basic/fundamental studies on the mechanisms of eye development and vision, to studies of the genetics and pathogenesis of eye disease, to transitional studies, to clinical trials, to epidemiological and international Studies f the worldwide causes of vision loss and disability. Wilmer has been fortunate to have been funded through an NEI Core Grant for Vision Research for over thirty-five years, and this funding has provided the infrastructure and core support for a wide variety of these studies. The support that the Core grant has provided has been a tremendous aid in facilitating Wilmer's diverse research programs and it has also encouraged a number of collaborative research projects. In this competitive renewal application, we are seeking support to continue these essential infrastructure and core activities. We are proposing both continuation of past services, but also modifying and re-directing some cores so as to better adapt to changing research needs, technologies, and priorities. The modules for which funding is requested are cores for Imaging and Microscopy, Biostatistics, Bioinformatics, Animal Modeling, and a new module on Drug Delivery and Nanotechnology. We feel that this new module structure, together with a rigorous administration support structure, will best serve and facilitate the diverse vision research activities at Wilmer and throughout Hopkins.