Cancer epidemiology cohorts in Shanghai and Singapore

描述（由申请方提供）：在本提案中，我们为两个已建立的基于人群的癌症流行病学队列提供了持续基础设施支持的依据，这两个队列在20世纪80年代末在上海和20世纪90年代初在新加坡基线时招募了81，501名中国男性和女性。需要基础设施支持，以便在未来五年内增加2，700个新的癌症病例，以实现开展创新研究的总体目标，评估环境和生活方式暴露以及遗传易感性如何共同影响癌症发病率，死亡率和与衰老有关的结果。除了收集问卷信息外，这两个亚洲队列还包括一个已建立的生物储存库，其中包括来自50，000多名参与者的血液，口腔和尿液样本。随着强有力的随访程序的实施，只有1.5%的原始队列参与者失去了随访。到目前为止，大约17%的队列成员被诊断患有偶发癌症;大约50%的癌症患者储存了生物标本。评估亚洲队列研究人群独特环境和生活方式暴露的研究提供了有助于癌症病因学和预防领域的新发现。这些新的发现部分为我们目前在美国人群中进行的化学预防试验提供了依据。在接下来的5年研究期间，我们建议：（1）开展核心基础设施活动，以维护和增强两个亚洲队列数据库，包括：（a）癌症、非癌症和死亡结局的随访，（B）生物储存库的维护，以及（c）数据库的管理;（2）对队列参与者进行面对面和电话访谈，以更新暴露和医疗信息;（3）从癌症诊断的队列参与者中收集血液和尿液样本;以及（4）参与NCI和Asian Consortia的合作研究项目。我们预计，随着两个亚洲队列的年轻成员进入癌症发病率最高的年龄，这两个亚洲队列的现有资源在未来五年内将变得更具科学价值，从而增加基于疾病前生物标志物的研究项目的数量。 相关性：我们正在请求为两个已建立的、基于人群的中国男性和女性癌症流行病学队列提供基础设施支持。亚洲人群独特的暴露和癌症风险特征对于确定保护作用至关重要 特定的饮食因素对癌症风险的影响。这些重要的发现已被用作在美国人群中进行癌症化学预防试验的理论基础。

DESCRIPTION (provided by applicant): In this proposal we provide a rationale for continued infrastructure support for two established, population based cancer epidemiology cohorts that enrolled 81,501 Chinese men and women at baseline in the late 1980s in Shanghai and in the early 1990s in Singapore. Infrastructure support is needed to accrue an additional 2,700 new cancer cases over the next five years to accomplish the overall goal of conducting innovative research that evaluates how environmental and lifestyle exposures, and genetic susceptibility together affect cancer incidence, mortality and aging-related outcomes. In addition to collecting questionnaire information, these two Asian cohorts include an established biorepository with blood, buccal and urine samples from more than 50,000 participants. With the vigorous follow-up procedures in place, only 1.5 percent of the original cohort participants have been lost to follow-up. To date, approximately 17 percent of the cohort members were diagnosed with incident cancers; approximately 50 percent of the cancer patients have stored biospecimens. Researches evaluating the unique environmental and lifestyle exposures of the Asian cohort study populations have provided novel findings that contributed to the field of cancer etiology and prevention. These novel findings in part provided the rationale for our current chemoprevention trials in U.S. populations. During the next 5-year study period, we propose to: (1) Conduct core infrastructure activities to maintain and enhance the two Asian cohort databases, including: (a) follow-up for cancer, non-cancer and death outcomes, (b) maintenance of the biorepositories, and (c) management of the databases; (2) Conduct in-person and telephone interviews among cohort participants to update exposure and medical information; (3) Collect blood and urine samples from cohort participants with cancer diagnoses; and (4) Engage in collaborative research projects of the NCI and Asian Consortium Consortia. We anticipate that the established resources of the two Asian cohorts will become even more scientifically valuable over the next five years as the younger members of the cohorts enter into the age of maximal cancer incidence, thereby increasing the number of pre-disease biomarker-based research projects. RELEVANCE: We are requesting infrastructure support for two established, population-based cancer epidemiology cohorts among Chinese men and women. The unique exposures and cancer risl< profiles of the Asian cohorts have been essential to identifying the protective effect of specific dietary factors on cancer risk. These important findings have been used as a rationale for conducting cancer chemoprevention trials in U.S. populations.