Translational Research Training inCancer Etiology & Prevention

癌症病因学转化研究培训

• 批准号: 10673621
• 负责人: Jian-Min Yuan
• 金额: $ 12.37万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-05 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10673621
• 关键词: Etiology; Prevention; Research Training; Translational Research

Given the severe shortfall of research scientists who are capable of conducting comprehensive studies that can translate fundamental knowledge from the bench to the clinical and the community settings for the improvement of cancer prevention and control, the purpose of this research training program is to provide integrated training in an inter-disciplinary research and teaching setting at the University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center. Trainees will be trained in understanding the role of environmental exposures and genetic and other physiological factors in the development and progression of cancer in humans. The training program involves cross-disciplinary training courses in different tracks in the Clinical Trial Research, the Translational Research, and the Population-Based Observational and Interventional Research on cancer. Trainees will work with experienced mentors in a multiple disciplinary team conducting researches from mechanistic experiments and observational studies in populations to randomized intervention studies to test the efficacy of chemo- and immuno-preventive agents on cancer protection in humans. The mentored research will provide direct research experience to trainees in study design, methodological development, implementation of research protocol, data collection, analysis and interpretation, and manuscript preparation and publication. Trainees also will learn how to translate discoveries from pre-clinical experimental and/or observational studies into randomized interventional studies for cancer prevention. The unique training of this program will train next generation of scientists who can lead the cutting-edge translational research on cancer etiology and prevention. This training program is a joint effort of 23 preceptors who are conducting active research projects all with independent research funding in University of Pittsburgh. These faculties are from the following research programs: Cancer Epidemiology and Prevention Program; Breast and Ovarian Cancer Program; Biobehavioral Oncology Program; Cancer Immunology Program; Cancer Therapeutics Program; Head & Neck Cancer Program; Lung Cancer Program; and Molecular and Cellular Cancer Biology Program at the UPMC Hillman Cancer, a top-ranked Comprehensive Cancer Center with $94 million direct research funding in 2017. Trainees will receive cutting-edge translational research training and experience. We request continuing funding to support 3 postdoctorates and one predoctorate per year for 5 years. Our recent data on applicant recruitment, retention and training experience demonstrate a relatively large pool of candidates with high academic performance. In addition, we successfully enrolled one-third trainees from the underrepresented racial and ethnical groups. The progress and success of the training program will continue to track the career development and research activities of past trainees in the 10 years post-training.

鉴于能够进行全面研究的研究科学家的严重短缺 这可以将基础知识从替补席转化为临床和社区环境 改善癌症预防和控制，本研究培训计划的目的是提供 匹兹堡医学大学跨学科研究和教学环境中的综合培训 (UPMC)希尔曼癌症中心。受训者将接受理解环境的作用的培训 暴露和遗传等生理因素在癌症发生发展中的作用 人类。该培训计划包括在临床不同轨道的跨学科培训课程 试探性研究、转化性研究和以人群为基础的观察和干预 对癌症的研究。学员将在一个多学科团队中与经验丰富的导师合作 从机制实验和群体观察研究到随机干预研究 测试化学和免疫预防药物对人类癌症保护效果的研究。这个 指导研究将为受训者提供直接的研究经验，包括研究设计、方法 研究方案的制定、执行、数据收集、分析和解释以及手稿 筹备和出版。学员还将学习如何将临床前实验的发现转化为 和/或用于癌症预防的随机介入研究的观察性研究。别开生面的培训 该计划将培养下一代科学家，他们可以领导尖端的翻译研究 癌症病因学和预防。 这一培训计划是由23名正在进行积极研究项目的导师共同努力的 由匹兹堡大学的独立研究资助。这些教职人员来自以下研究 计划：癌症流行病学和预防计划；乳腺癌和卵巢癌计划；生物行为计划 肿瘤学计划；癌症免疫学计划；癌症治疗计划；头颈癌 项目；肺癌项目；分子和细胞癌生物学项目 癌症，一家排名第一的综合癌症中心，2017年直接研究资金为9400万美元。实习生 将接受尖端的翻译研究培训和经验。 我们要求继续资助每年3名博士后和1名博士后，为期5年。 我们最近关于应聘者招聘、留住和培训经验的数据表明，我们有一个相对较大的人才库 学习成绩优异的应聘者。此外，我们还成功招收了三分之一的学员 代表不足的种族和民族群体。培训计划的进展和成功将 继续跟踪过去学员在培训后10年的职业发展和研究活动。

项目成果

Association between Dietary Tomato Intake and the Risk of Hepatocellular Carcinoma: The Singapore Chinese Health Study.

• DOI: 10.1158/1055-9965.epi-20-0051
• 发表时间: 2020-07
• 期刊: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
• 作者: Thomas CE;Luu HN;Wang R;Adams-Haduch J;Jin A;Koh WP;Yuan JM
• 通讯作者: Yuan JM

Serum Biomarkers of Iron Status and Risk of Hepatocellular Carcinoma Development in Patients with Nonalcoholic Fatty Liver Disease.

• DOI: 10.1158/1055-9965.epi-21-0754
• 发表时间: 2022-01
• 期刊: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

The Association between Peptic Ulcer Disease and Gastric Cancer: Results from the Stomach Cancer Pooling (StoP) Project Consortium.

• DOI: 10.3390/cancers14194905
• 发表时间: 2022-10-07
• 期刊: Cancers
• 影响因子: 5.2

High serum magnesium is associated with lower risk of hepatocellular carcinoma among patients with nonalcoholic fatty liver disease.

高血清镁与非酒精性脂肪肝患者患肝细胞癌的风险较低相关。

• DOI: 10.1002/cncr.34799
• 发表时间: 2023
• 期刊: Cancer
• 影响因子: 6.2
• 作者: Yu,Yi-Chuan;Paragomi,Pedram;Wang,Renwei;Liang,Feiran;Luu,HungN;Behari,Jaideep;Yuan,Jian-Min
• 通讯作者: Yuan,Jian-Min

Worldwide Variations in Demographics, Management, and Outcomes of Acute Pancreatitis.

• DOI: 10.1016/j.cgh.2019.11.017
• 发表时间: 2020-06
• 期刊: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association