Third Biennial Symposium on Age Related Macular Degeneration

描述（由申请人提供）：资金被要求支持第三届两年一度的研讨会上视网膜相关的黄斑变性（AMD）将于2014年10月23日和25日在斯塔尔中心科学通信在Schepens眼科研究所（SERI）。会议由Patricia A. D 'Amore博士，SERI的研究主任，大众眼耳（Mass Eye and Ear）; Ijam Kim博士，SERI的视网膜专家;以及Joan米勒博士，SERI的眼科主任和哈佛医学院眼科系主任。这次会议将在分别于2010年9月和2012年9月举行的第一次和第二次双年度会议取得巨大成功的基础上再接再厉。AMD是工业化国家50岁或以上人群中不可逆失明的主要原因。超过800万美国人患有AMD，并且由于人口老龄化，预计到2020年AMD的患病率将增加超过50%。鉴于这些人口统计数据，对AMD发病机制的不完全理解使得这是一个及时和重要的会议。本次会议的目标是激发讨论和合作，旨在阐明AMD发展的机制，从而确定治疗，治愈和最终预防AMD的方法。本次会议的形式将与其他关于AMD的会议不同，这使得有大量的时间进行讨论。另一个独特的特点是包括发言者谁将突出AMD和其他系统性表现的老化，如心血管疾病，脂质生物学和其他神经退行性疾病之间的相似之处。该领域的领导者琼·米勒博士将发表主题演讲，罗伯特·达马托博士将发表总结和结论性讲话。将涵盖的主题包括：视网膜色素上皮细胞移植、视网膜和脉络膜血管、炎症、病理学新概念（ER应激、疾病中的microRNA、代谢）、视网膜色素上皮生物学、神经保护和再生、成像和动物模型。将提供旅费奖励，以吸引研究生和研究员，特别重视代表性不足的少数群体和残疾人。

DESCRIPTION (provided by applicant): Funds are requested to support The Third Biennial Symposium on Age-related Macular Degeneration (AMD) to be held October 23 & 25, 2014 in the Starr Center for Scientific Communications at the Schepens Eye Research Institute (SERI). The meeting is co-organized by Drs. Patricia A. D'Amore, Director of Research at SERI, Mass Eye and Ear (MEE); Dr. Ivana Kim, a retinal specialist at MEE; and, Dr. Joan Miller Chief of Ophthalmology at MEE and Chair of the Department of Ophthalmology at Harvard Medical School. This meeting will build on the strong successes of the first and second biennial meetings that were held in September 2010 and September 2012, respectively. AMD is the leading cause of irreversible blindness in industrialized countries in people 50 years or older. More than eight million Americans have AMD, and as a result of the aging population, the prevalence of AMD is expected to increase by more than 50% by the year 2020. In light of these demographics, the incomplete understanding of the pathogenesis of AMD makes this a timely and important meeting. The goal of this conference is to stimulate discussion and collaborations aimed at elucidating the mechanisms that underlie the development of AMD and, thus, to identify means to treat, cure, and ultimately prevent AMD. This meeting will be distinct from other meetings on AMD in its format, which allows significant time for discussion. An additional unique feature is the inclusion of speakers who will highlight the parallels between AMD and other systemic manifestations of aging such as cardiovascular disease, lipid biology, and other neurodegenerative diseases. Dr. Joan Miller, a leader in the field, will present the Keynote address, and Dr. Robert D'Amato will deliver a summary and concluding remarks. Topics to be covered include: retinal pigment epithelial cell transplantation, retinal and choroidal vasculatures, inflammation, new concepts in pathology (ER stress, microRNAs in disease, metabolism), retinal pigment epithelial biology, neuroprotection and regeneration, imaging, and animal models. Travel awards will be provided to attract graduate students and fellows, with a particular emphasis on under-represented minorities and persons with disabilities.