Child Health Research Career Development Award

国家儿童医学中心/儿童研究中心的CHRCDA项目的主要目的是促进儿科初级教员成功地发展基础科学/转化性研究事业。这个项目的基本原理是，虽然有很多机会利用分子生物学来推进儿科疾病的治疗，但这项技术复杂、劳动密集型，而且是基于对当前科学进步的全面理解。然而，在学术儿科医生的传统职业发展中，缺乏延长的板凳经验。CHRCDA回应了这一需求。它为初级儿科医生研究人员提供时间：1)学习与其研究相关的基础科学领域的课程；2)学习最先进的实验室方法；3)在知名研究人员的监督下开发初步数据，以提交独立的NIH拨款申请；以及4)学习有效地将他们在儿科研究方面的成就转化为改善儿童健康。为了实现这一目标，CHRCDA学者将花费至少75%的努力在2-5年的时间内磨练这些技能，这取决于过去的经验和主题领域。在此期间，以系统的方式处理上述每个领域，包括参加研究方法和生物统计学的核心课程，以及在现有调查员/导师的实验室开展日益独立的研究。我们在神经科学、遗传学、分子生理学和细胞生物学四个领域推荐了15位导师。中心的行政结构包括中心的一名首席调查员/项目主任、一名培训主任、一名少数族裔招募主任以及内部和外部咨询委员会。我们建议在资助期内，遴选和培训8名中华文化艺术发展局助理教授级学者。

The primary purpose of the CHRCDA program at the Children's National Medical Center/Children's Research is to facilitate the development of successful basic science/translational research careers of junior faculty members in pediatrics. The rationale for this program is that while there are many opportunities to use molecular biology to advance treatment of pediatric diseases, the technology is complex, labor intensive and based on a comprehensive understanding of current scientific advances. Yet, extended bench experience is lacking in the traditional career development of academic pediatricians. The CHRCDA responds to this need. It provides time for junior pediatrician investigators to: 1) take coursework in basic science areas relevant to their research; 2) learn state-of-the art laboratory methodology; 3) develop preliminary data under the supervision of an established investigator that will lead to submission of an independent NIH grant application; and 4) learn to effectively translate their accomplishments in pediatric research to the improvement of child health. In order to accomplish this goal the CHRCDA Scholars will spend at least 75% effort honing these skills over a 2-5 year period of time, depending on past experience and topic area. During this period each of the above areas is addressed in a systematic fashion including participation in a core curriculum in research methodology and biostatistics and performance of increasingly independent research in the laboratory of an Established Investigator/Mentor. We propose 15 mentors in 4 affinity areas: neuroscience, genetics, molecular physiology, and cell biology. The administrative structure of the CHRCDA includes a Principal Investigator/Program Director of the CHRCDA Center, a Training Director, a Director of Minority Recruitment and internal and external advisory committees. We propose to select and train a total of 8 CHRCDA Scholars at the Assistant Professor level during the grant period.