Mechanisms of Breast Development and Carcinogenesis

组织病理学核心B组由乳腺病理学家安德里亚·理查森博士指导。这个共享的资源核心将与Brown博士合作，提供ER和HER2免疫表型的新鲜人乳腺肿瘤样本，用于生成早期传代可移植的人鼠异种移植物。组织和病理核心将表征异种移植肿瘤，并与配对的原始人类肿瘤进行组织形态学，免疫表型和分子（基因表达和突变）分析。这些异种移植模型将用于项目1、

The Tissue and Pathology core B is directed by breast pathologist, Dr. Andrea Richardson. This shared resource core will provide fresh human breast tumor samples of each of the ER and HER2 immunophenotypes for generation of early passage transplantable human-in-mouse xenografts in collaboration with Dr. Brown. The tissue and pathology core will characterize the xenograft tumors and compare to the paired original human tumor for histomorphology, immunophenotype, and molecular (gene expression and mutation) profiling. These xenograft models will be used for studies proposed in projects 1, 2, 4 and 6. The core will provide fresh breast tissue from women without cancer (breast reductions) and from women with germline BRCA1 or BRCA2 mutation for isolation of epithelial progenitor cells for studies proposed in projects 2 and 5. The tissues collected are from women who provided informed consent to one of our research banking protocols that allows for collection of excess tissues from clinical specimens for research and for collection of and linkage to long term outcome data. In addition, the core will provide research pathology services to perform histopathology analysis of mouse tumor models in projects 3 and 4.