Stellenbosch University Clinical Trials Unit (SUN-CTU)

描述(申请人提供)：我们的总体目标是通过高质量的研究、创新和实施不断完善，为所有种族、年龄和性别的个人提供安全、有效、实用、以家庭为中心的综合预防、治疗和治疗艾滋病毒、结核病和其他合并症。艾滋病毒/艾滋病和结核病是主要的全球公共卫生问题。南非是全球艾滋病毒感染率最高的国家，也是世界上发病率最高的国家，60%的结核病病例也是艾滋病毒感染者。SUN-CTU位于南非西开普省开普敦市区的医学和健康科学学院，是这两种流行病的中心，为大约250万人口提供服务。Sun-CTU将卓越的研究和临床护理与艾滋病毒和结核病的高流行率以及通过三个紧密联系的临床研究网站(CRSS)访问的人口结合在一起，这些网站具有互补的研究重点、战略位置的卫星和经证明的广泛研究能力。SUN-CTU有一种强有力的以家庭为中心的方法，专注于与艾滋病毒和结核病相关的研究和对大量高危人群的护理，包括低出生体重和早产儿、婴儿、儿童、青少年和所有年龄段的成年人。拟议的整合良好的SUN-CTU是现有较小CTU的多功能网络扩展，该CTU设在儿童传染病临床研究股(KID-CRU)，侧重于IMPAACT网络活动。Sun-CTU已经证明有相当大的能力通过NIAID和其他资金来源进行多个临床研究项目，并特别适合参与IMPAACT、ACTG和HPTN网络。

DESCRIPTION (provided by the applicant): Our overall objective is to provide safe, effective, practical family-centered and integrated prevention, treatment and cure for HIV, TB and other comorbidities in individuals of all races, ages and gender, continuously refined through quality research, innovation and implementation. HIV/AIDS and TB are major global public health problems. South Africa has the highest population prevalence of HIV infection globally and the highest incidence in the world, with >60% of TB cases also HIV-infected. The SUN-CTU is located at the Faculty of Medicine and Health Sciences in urban Cape Town, Western Cape Province of South Africa, an epicenter of these twin epidemics, serving a population of approximately 2.5 million. SUN-CTU combines excellence in research and clinical care with a high prevalence of HIV and TB and populations accessed through 3 closely linked Clinical Research Sites (CRSs) with complementary research focus, strategically situated satellites and proven capacity for a broad spectrum of research. SUN-CTU has a strong family-centered approach, focusing on HIV- and TB-related research and care to large at-risk populations, spanning low birth weight and premature neonates, infants, children, adolescents and adults of all ages. The proposed well-integrated SUN-CTU is a pluripotent network expansion of an existing smaller CTU, at the Children's Infectious Diseases Clinical Research Unit (KID-CRU), focused on IMPAACT network activities. SUN-CTU has already demonstrated considerable capacity to conduct multiple clinical research projects through NIAID and other funding sources, and is particularly well aligned for participation in the IMPAACT, ACTG and HPTN networks.