Investigating the role of aberrant splicing (intron retention) in acute myeloid leukaemia

2013年，我们有了一个突破性的发现，基因的某些部分，以前被认为是“垃圾DNA”，实际上携带着控制细胞中蛋白质产量的信号。我们现在的初步工作表明，这些控制蛋白质水平的信号在癌症中可能是错误的。在这里，我们希望确定这些错误的信号是否会导致一种致命的血液癌症，称为急性髓性白血病（AML）。我们的目标是破译以前未知的AML病因，从而刺激新的治疗方法。

In 2013, we made a breakthrough discovery that certain parts of genes, previously considered “Junk DNA”, are actually carrying signals to control the amount of proteins produced in cells. Our preliminary work now suggests these signals controlling protein levels can be faulty in cancers. Here, we wish to determine whether these faulty signals could cause a deadly blood cancer called acute myeloid leukaemia (AML). We aim to decipher previously unknown causes of AML that will spur novel therapies.