Clinical Translation of Augmented Reality Visualization for Laparoscopic Surgery

描述(由申请人提供)：拟议研究的总体目标是全面开发和进行一项新技术的临床翻译，该技术为微创外科医生提供了可视化暴露的器官表面及其隐藏的结构的能力，并真正认识到深度。微创腹腔镜手术的一个长期需求是在解剖前观察结构的内部和周围，这一需求目前使用的腹腔镜，即使是高清晰度和立体的，也无法满足。我们计划通过集成两种实时外科成像方式来实现我们的目标：(1)新出现的三维(3D)腹腔镜摄像技术，允许以目前可用的最高图像质量和对真实深度的感知来可视化手术解剖结构，以及(2)能够可视化隐藏结构的腹腔镜超声。我们将由此产生的可视化能力称为立体增强现实(AR)，其中3D腹腔镜视频(现实)被超声发现增强，特别是血管。儿童国家医学中心和IGI科技公司将结合他们互补的专业知识，以实现该项目的目标。儿童国家医院，最初的研发地点，带来了无与伦比的临床影像引导手术专业知识和资源，以促进临床翻译。IGI Technologies是一家医疗成像小企业，专注于将学术研究转化为产品。总体而言，本研究的具体目标是：(1)创建一个紧凑、高性能、可供操作室使用的3D AR可视化系统，以及(2)测试、演示和表征3D AR可视化系统。这些目标旨在开发一个临床上可行的系统，并测试与可接受的图像覆盖精度和系统响应性相关的2个里程碑。达到这些里程碑将标志着第一阶段的成功完成，以及我们准备过渡到第二阶段，这将包括对开发的系统进行动物和人体测试。所提出的系统是新颖的，因为没有结合3D腹腔镜视频和超声的临床系统存在。这项拟议研究的成功实施将创建一种智能手术可视化系统，有望为外科医生提供更大的信心，最大限度地减少并发症，缩短手术时间，减少失血，并有助于将微创手术的使用率扩大到目前在所有手术中的9%-12%以上。预期的好处将同样适用于儿科和成人手术。

DESCRIPTION (provided by applicant): The overall objective of the proposed research is to fully develop and conduct clinical translation of a novel technology that provides minimally invasive surgeons an ability to visualize exposed organ surfaces as well as structures hidden by them, together with a true appreciation of depth. A long-standing need in minimally invasive laparoscopic surgery has been to see inside and around a structure before dissecting, a need that currently used laparoscopes, even when high- definition and stereoscopic, cannot meet. We plan to achieve our objective by integrating 2 real- time surgical imaging modalities: (1) newly emerged 3-dimensional (3D) laparoscopic camera technology that allows visualizing the surgical anatomy with the highest image quality currently available and perception of true depth, and (2) laparoscopic ultrasound capable of visualizing hidden structures. We call the resulting visualization capability stereoscopic augmented reality (AR), in which 3D laparoscopic video (the reality) is augmented with ultrasound findings, especially the blood vessels. Children's National Medical Center and IGI Technologies will combine their complementary expertise to meet the goals of this project. Children's National, the site of the original research and development, brings unparalleled clinical image-guided surgery expertise and resources to facilitate clinical translation. IGI Technologies, a medical imaging small business, focuses on converting academic research into products. Overall, the specific aims of the proposed research are to: (1) create a compact, high-performance, operating room-ready 3D AR visualization system, and (2) test, demonstrate, and characterize the 3D AR visualization system. These aims are designed to develop a clinically viable system and test 2 milestones relating to acceptable image overlay accuracy and system responsiveness. Meeting these milestones will signal successful completion of Phase I and our readiness to transition to Phase II, which will include animal and human testing of the developed system. The proposed system is novel in that no clinical system that combines 3D laparoscopic video and ultrasound exits. Successful execution of the proposed research will create a smart surgical visualization system that promises to provide surgeons greater confidence, minimize complications, shorten procedure times, reduce blood loss, and help expand the utilization of minimally invasive surgeries to beyond their 9%-12% current share of all surgeries. The anticipated benefits will apply equally to pediatric and adult surgery.