Center for Transdisciplinary ELSI Research in Translational Genomics

描述(申请人提供)：收获基因组学的好处需要一种新的跨学科合作。在接下来的三年里，我们将创建翻译基因组学跨学科ELSL研究中心(CT2G)，以解决翻译研究中的关键ELSL问题。拟议的中心汇集了北加州凯撒永久大学(KPNC)及其研究部和加州大学旧金山分校(UCSF)的独特资源，包括法律、科学和卫生政策法律联盟的黑斯廷斯学院(Hastings College of the Law，Science&Health Policy)。用于培训、研究、审议和政策分析的关键CT2G资源是Kaiser Permanente“基因、环境和健康研究计划”(RPGEH)，旨在促进流行病学研究。RPGEH将参与者来自电子医疗记录、生物显微镜、健康调查和地理信息系统的数据联系在一起。RPGEH包括来自超过11万名男性和女性样本的全基因组遗传数据和端粒长度测量，这些样本构成了成人健康和老龄化遗传流行病学研究(GERA)队列。深化KPNC和加州大学旧金山分校科学家和临床医生之间的现有合作，并利用KPNC集成医疗保健提供系统的独特结构，我们的目标是： 1)创建CT2G并培育其发展成为ELS1翻译基因组研究的新资源。 *实施管理计划，并成立指导委员会和外部咨询小组 *通过网站、系列研讨会和年度会议发展强大的知识分子社区 *资助小型试点项目，以阐明有效进行基因组学翻译的障碍 2)召开KPNC/UCSF联合工作组，解决翻译基因组学中的关键问题。聚焦于有切实成果的项目，我们将把尚未合作的学者聚集在一起，为长期的跨学科工作创造一个蓝图，将经验方法和规范方法结合起来。 3)计划并启动一项以博士生和临床医生为中心的英语学习教育计划。 *为了扩大代表不足的少数族裔ELSL学者的人数，我们将计划并获得批准，为来自一系列学科的学生提供博士前奖学金计划。 *为了加强跨学科合作，我们将为来自多个领域的临床医生开发为期一年的ELSL奖学金，包括护理、药剂学、遗传咨询和临床医学。

DESCRIPTION (provided by applicant): Harvesting the benefits of genomics requires a new kind of transdisciplinary cooperation. Over the next three years, we will create the Center for Transdisciplinary ELSl Research in Translational Genomics (CT2G) to address key ELSl questions in translational research. The proposed Center brings together the unique resources of Kaiser Permanente Northern California (KPNC), including its Division of Research, and the University of California, San Francisco (UCSF), including the Hastings College of the Law Consortium on Law, Science & Health Policy. A key CT2G resource for training, research, deliberation, and policy analysis is the Kaiser Permanente "Research Program on Genes, Environment, and Health" (RPGEH), designed to foster epidemiological studies. The RPGEH links together participants' data from electronic medical records, biospecimens, health surveys and geographic information systems. The RPGEH includes genome-wide genetic data and measures of telomere length from a sample of over 110,000 men and women, who constitute the Genetic Epidemiology Research in Adult Health and Aging (GERA) cohort. Deepening the existing collaborations between scientists and clinicians at KPNC and UCSF, and utilizing the unique structure of KPNC's integrated health care delivery system, we aim to: 1) Create CT2G and nurture its development as a novel resource for ELSl research in translational genomics. * Implement a management plan and form a Steering Committee and External Advisory Panel * Develop a strong intellectual community through a website, seminar series, and annual conferences * Fund small pilot projects to elucidate barriers to effective genomics translation 2) Convene joint KPNC/UCSF working groups to address critical issues in translational genomics. Focusing on projects with tangible outcomes, we will bring together scholars who have not yet collaborated, creating a blueprint for long-term transdisciplinary work that joins empirical and normative approaches. 3) Plan and initiate a program in ELSl education focused on pre-doctoral students and clinicians. * To expand the pool of under-represented minority ELSl scholars, we will plan and gain approval for a pre-doctoral fellowship program for students from a range of disciplines. * To enhance transdisciplinary collaboration, we will develop a one year ELSl fellowship for clinicians from multiple fields, including nursing, pharmacy, genetic counseling, and clinical medicine.