Spore in Head and Neck Cancer

这是约翰霍普金斯大学医学院头颈癌卓越研究专业计划（SPORE）的延续申请，支持高度互动，多学科和机构内的计划。提出了五个研究项目，三个核心，职业发展和研究发展计划，以开展我们在头颈癌的转化研究。在所有项目中，孢子都将HPV感染的存在和不存在作为疾病生物学和行为的主要决定因素。此外，有两个主题贯穿我们的主要项目，一个是基因组学和生物学，另一个是免疫学。 研究项目#1-通过磷酸二酯酶5型抑制增强头颈部鳞状细胞癌的免疫反应-共同研究者，Ivan Borrello（基础）和Joseph Califano（临床）。研究项目#2 - HNSCC从癌症基因组学到个性化生物标志物。- 合作研究者，大卫Sidransky（基础）和Nishant Agrawal（诊所）。研究项目#3 -通过对抗TGF-β介导的免疫抑制来改善EGFR靶向免疫治疗HNSCC-共同研究者，克莉丝汀钟（诊所）和AtuI Bedl（基础）。研究项目#4 - HPV疫苗治疗-合作研究者Sara Jiang（诊所）和T.C. Wu（基础）项目#5 -头颈部鳞状细胞的病因学异质性-合作研究者，Gypsyamber D 'Souza（基础）和Carole Fakhry（临床） 核心支持研究计划（核心#1 -病理学/组织核心，Westra博士;核心#2 -行政/临床核心（Sidransky博士），核心#3 -生物统计学和生物信息学核心（Rosner博士）职业发展计划（Sidransky博士）有助于新研究者的出现，研究发展计划（大卫Sidransky博士）为创新方向提供快速资助。

This application for continuation for the Specialized Program of Research Excellence (SPORE) in Head and Neck Cancer at the Johns Hopkins University School of Medicine supports a highly interactive, multidisciplinary, and intrainstitutional program. Five research projects, three cores, a career development and a research developmental program are proposed to carry out our translational research in head and neck cancer. The SPORE has given attention in all projects to the presence and absence of HPV infection as a major determinant of disease biology and behavior. Moreover, there are two main themes that permeate our major projects, one is genomics and biology and the other is immunology. Research Project #1- Augmentation of Immune Response to Head and Neck Squamous Cell Carcinoma via Phosphodiesterase Type 5 Inhibition - Co-Investigators, Ivan Borrello (basic) and Joseph Califano (clinic). Research Project #2 - HNSCC From Cancer Genomics to Personalized Biomarkers. - Co-Investigators, David Sidransky (basic) and Nishant Agrawal (clinic). Research Project #3 - Improving EGFR-targeted Immunotherapy of HNSCC by Counteracting TGF- ¿ -mediated Immune Suppression - Co-Investigators, Christine Chung (clinic) and AtuI Bedl (basic). Research Project #4 - HPV Vaccine Therapy - Co-Investigators Sara Pal (clinic) and T.C. Wu (basic) Project #5 - Etiologic Heterogeneity in Head and Neck Squamous - Co-Investigators, Gypsyamber D'Souza (basic) and Carole Fakhry (clinic) The cores support the research programs (Core #1 - Pathology/ Tissue Core, Dr. Westra; and Core #2 - Administrative/Clinical Core (Dr. Sidransky), Core #3 - Biostatistics and Bioinformatics Core (Dr. Rosner) The Career Development Program(Dr. Sidransky) aids the emergence of new investigators and the Research Developmental Program (Dr. David Sidransky) provides rapid funding of innovative directions.