Training Grant in Clinical Pharmacology

描述（由申请人提供）：本提案请求继续资助美国国立卫生研究院在梅奥诊所-梅奥诊所医学院-梅奥医学院资助的临床药理学奖学金培训计划。该计划的基础是在应用于人药相互作用的最先进的生物医学技术方面进行强有力的研究培训。梅奥临床药理学培训经验包括一个课程，系统地暴露学员的科学的关键方面，基础临床药理学。培训的核心是在一个支持性的指导环境中获得杰出的个人研究经验。临床药理学是一门研究药物与生物系统相互作用的“桥梁学科”。然而，在生物医学领域正在发生的“革命”的背景下，一场有望改变医疗实践的革命，临床药理学是分子药理学、基因组学、蛋白质组学、生物信息学和理性疗法的融合，其最终目标是真正的“个性化”药物治疗。具体来说，临床药理学旨在加强我们对药物反应的分子基础的理解，并在翻译界面上应用这些信息，以便根据潜在的疾病过程和每个患者的独特特征定制药物治疗。我们有能力利用生物医学科学的巨大进步所代表的机会来实现这些目标，这就要求我们在“系统临床药理学”方面培养新一代的临床药理学家。大型、全面、综合的学术医疗中心，如梅奥诊所，是培养新一代临床药理学家的理想场所。梅奥之所以能够做到这一点，是因为它有悠久的整合历史

DESCRIPTION (provided by applicant): This proposal represents a request for continued funding of the NIH-sponsored Clinical Pharmacology Fellowship Training Program at the Mayo Clinic-Mayo Clinic College of Medicine-Mayo Medical School. The foundation for this program is strong research training in state-of-the-art biomedical techniques as applied to human-drug interactions. The Mayo Clinical Pharmacology training experience includes a curriculum that systematically exposes Trainees to critical aspects of the science that underlies Clinical Pharmacology. At the heart of the training is an outstanding individual research experience within a supportive mentoring environment. Clinical Pharmacology is a "bridge discipline" devoted to the study of the interaction between drugs and biological systems. However, within the context of the ongoing "revolution" that is occurring in biomedical science, a revolution that promises to transform medical practice, Clinical Pharmacology lies at the confluence of molecular pharmacology, genomics, proteomics, bioinformatics and rational therapeutics-with an ultimate goal of truly "individualized" drug therapy. Specifically, Clinical Pharmacology seeks to enhance our understanding of the molecular basis for drug response and the application of that information at the translational interface to make it possible to tailor drug therapy to both he underlying disease process and the unique characteristics of each individual patient. Our ability to take advantage of the opportunity represented by the dramatic advances that are occurring in biomedical science to achieve those goals will require that we train a new generation of Clinical Pharmacologists in "Systems Clinical Pharmacology". Large, comprehensive, integrated academic medical centers like the Mayo Clinic are ideally positioned to train this new generation of Clinical Pharmacologists. Mayo is able to do that because of its long history of the integration of basic and clinical medical research, because of a tradition of continuous contribution to the discipline of Clinical Pharmacology and because the Mayo Clinical Pharmacology Training Program has had decades of experience in successfully recruiting and training both physician scientists and laboratory-based translational scientists in Clinical Pharmacology. During the next funding cycle, the Mayo Clinical Pharmacology Fellowship Training Program will continue to emphasize strong laboratory-based research training in a supportive mentored environment joined with systematic exposure to developments in clinical science, with an emphasis on the rapidly evolving nature of biomedical science-all directed toward the goal of preparing each Fellow enrolled in the Program to become a future leader in Clinical Pharmacology.