Midcareer Mentoring Award for Patient Oriented Research in Geriatric Cardiology

申请者的学术生涯表明他长期致力于以病人为导向的研究， 在年龄相关性心血管疾病的病理生理学研究方面具有丰富的专业知识 不成比例地困扰老年人，包括收缩功能保留的心力衰竭和 在指导住院医师、心脏病研究员和初级教职员工方面取得了成功 心脏科。申请者的职业规划是将他的研究兴趣扩展到多学科 以射血功能正常的心力衰竭为研究对象的年龄相关性心血管疾病 分数，占美国心力衰竭病例的一半以上， 以老年人为主。在本奖项的有效期内，申请人将进一步获得 在梅尔曼公共卫生学院通过正规课程进行遗传学培训，加强 与哥伦比亚大学的基础和临床研究人员建立新的合作关系 大学，并为来自中国的年轻临床研究人员建立一个成功的指导计划 老年病学和心脏病学，将促进跨学科合作调查。后者将 将通过创建大纽约老年心脏病联盟(GNYGCC)实现 旨在改善老年心血管疾病患者的护理，通过组织和 提供老年心脏病学课程，作为专业医学教育活动的一部分 随后，通过实施创新的、由研究人员发起的多中心协作临床 调查。建议的辅导计划由其他三个部分组成：1)强化 以病人为导向的研究中的个性化培训；2)哥伦比亚大学的教学计划 临床试验设计、数据分析、拨款撰写和伦理；3)由患者团队进行的批判性审查 以研究为导向的专家。授予PatientOriented Research职业生涯中期研究人员奖 将为实现这些职业目标提供急需的保护时间。哥伦比亚提供了强大的 支持申请人职业发展的制度环境。美国商务部 内科和心脏科承诺保护申请者50%的时间 用于以病人为导向的研究和指导。建议的目标是评估：(1)是否有针对性 贫血是导致HFNEF综合征的许多心外因素之一， 与改善的心功能、功能容量和健康状况有关。(2)对于潜力 引起或促成神经痛(能量缺乏)的病理生理机制的差异 心力衰竭受试者按射血分数保留或减少进行分层，以及(3)心室 使用无创压力容量分析和活动描记术的力学和功能容量 在接受经皮主动脉瓣置换术的老年人中。拟议的研究将会取得进展 申请者的职业发展，并提供一种机制，使受训者能够获得必要的 具备开展研究和收集数据以支持拨款申请的技能。最终目标是 促进心脏病和老年病学的新一代研究人员的发展 可以在老龄化的心血管疾病领域进行临床研究。

The applicant's academic career demonstrates a longterm commitment to patientoriented research, extensive expertise in the study of the pathophysiology of age related cardiovascular disorders that disproportionately afflict older adults including heart failure with preserved systolic function and a successful record in mentoring residents, cardiology fellows and junior faculty in geriatrics and cardiology. The career plan of the applicant is to expand his research interests to multidisciplinary studies of age related cardiovascular conditions by focusing on heart failure with a normal ejection fraction, which accounts for more than half of the cases of heart failure in the United States and that afflicts predominately older adults. During the tenure of this award, the applicant will gain further training in genetics through formal coursework at the Mailman School of Public Health, strengthen existing and form new collaborative relationships with basic and clinical investigators at Columbia University, and institute a successful mentoring program for young clinical investigators from geriatrics and cardiology that will foster collaborative interdisciplinary investigations. The latter will be achieved by the creation of the Greater New York Geriatric Cardiology Consortium (GNYGCC) aimed at improving the care of older adult patients with cardiovascular disease by organizing and delivering a curriculum in geriatric cardiology as part of professional medical education activities and subsequently by performing innovative, investigatorinitiated, multicenter collaborative clinical investigation. The proposed mentoring program consists of three other components: 1) intensive individualized training in patientoriented research; 2) Columbia University didactic programs on clinical trial design, data analysis, grant writing, and ethics; 3) critical review by a team of patient oriented research experts. Awarding a Midcareer Investigator Award in PatientOriented Research will provide critically needed protected time to achieve these career goals. Columbia provides a strong institutional environment for support of the applicant's career development. The Department of Internal Medicine and Division of Cardiology have committed to protect e50% of the applicant's time for patientoriented research and mentoring. The proposed aims are to evaluate: (1) whether targeting anemia, one of many extracardiac factors that could contribute to the syndrome of HFNEF, is associated with improved ventricular function, functional capacity and health status. (2) for potential differences in pathophysiologic mechanisms that cause or contribute to anergia (lack of energy) in heart failure subjects stratified by a preserved or a reduced ejection fraction and (3) ventricular mechanics and functional capacity using use of noninvasive pressure volume analysis and actigraphy in older adults undergoing percutaneous aortic valve replacement. The proposed studies will advance applicant career development and provide a mechanism by which trainees can acquire the necessary skills to launch a research career and collect data to support grant applications. The ultimate goal is to facilitate the development of a new generation of investigators from both cardiology and geriatrics that can pursue clinical research in the arena of aging cardiovascular disease.