Predoctoral Training in Exercise Physiology and Aging

马里兰州大学帕克分校运动生物学和衰老项目的运动机能学系 培养训练有素的博士，完成博士后培训并成为富有成效的教师的历史 成员我们已经支持了18名学员在前9年的这个计划与12完成他们的博士学位 其中5人仍在接受培训，1人正在攻读不同学科（神经科学）的MD/PhD学位。十一 毕业的12人中（92%）已经进入NIH博士后研究奖学金。这12个中的7个 毕业生现在在终身制的学术职位，1是在工业，1是兼职教师，3仍在 博士后职位此外，我们有3名非洲裔美国妇女毕业，她们继续 美国国立卫生研究院博士后研究奖学金在UT西南，维克森林，和寺。这个程序 为学员提供完成高质量论文研究项目所需的技能 解决：1）身体组成、代谢、CV和肌肉骨骼功能的年龄相关变化，以及 心血管疾病风险因素; 2）运动训练引起的这些相同参数的变化; 3）遗传因素 这些参数的基线测量的基础架构，它们随衰老的变化，以及它们的 运动训练干预的变化;和4）负责这些反应的机制， 使用细胞和分子生物学方法的动物和细胞培养模型。一个实质性的增强 这一更新培训计划的一个组成部分是翻译，学员可以借此延长他们的学习 从人类生理学研究到动物模型和细胞培养的研究， 潜在的细胞和分子机制。学员的研究可以与小学，中学， 以及马里兰州医学院密切合作实验室的副导师 老年学系、内分泌学、糖尿病和营养学系、生理学系， 护理和儿童学院国家医学中心遗传医学研究中心。学员 完成衰老基础生物学课程;运动，CV，肌肉骨骼， 代谢、细胞和分子生物学和生理学;遗传学;生物统计学和研究设计。我们 我建议继续这个项目，资助6名博士前学员每人4年完成博士学位 学位与高质量的课程和论文研究项目，将为他们准备一个国家卫生研究院 博士后研究奖学金和最终的学术教师职位与研究计划 专注于运动生物学和衰老。 相关性（参见说明）： 该计划将支持6名学员/年完成他们的博士学位与高质量的论文 研究项目。长期目标是培养受训者从事高水平的NIH博士后研究 奖学金，并最终，学术教师的立场，重点是研究和教学，在预防 与年龄相关的主要问题，如肌肉减少症、肥胖症、糖尿病、高血压和心血管疾病。

The University of Maryland College Park Department of Kinesiology exercise biology and aging program has a history of producing well-trained PhDs who complete postdoctoral training and become productive faculty members. We have supported 18 trainees over the first 9 yrs of this program with 12 completing their PhD degrees, 5 still in training, and 1 pursuing an MD/PhD degree in a different discipline (neuroscience). Eleven of the 12 who graduated (92%) have gone on to NIH postdoctoral research fellowships. Seven of these 12 graduates are now in tenure-track academic positions, 1 is in industry, 1 is part-time faculty, and 3 are still in postdoctoral positions. Furthermore, we have graduated 3 African-American women who have gone on to NIH postdoctoral research fellowships at UT-Southwestern, Wake Forest, and Temple. This program provides trainees with the skills necessary for them to complete high-quality dissertation research projects addressing: 1) age-related changes in body composition, metabolic, CV, and musculoskeletal function, and CV disease risk factors; 2) exercise training-induced changes in these same parameters; 3) the genetic architecture underlying the baseline measures of these parameters, their changes with aging, and their changes with exercise training interventions; and 4) the mechanisms responsible for these responses in animal and cell culture models using cell and molecular biology methodologies. A substantial enhancement of this renewal Training Program is this translational component, whereby trainees can extend their studies from human physiological studies to investigations in animal models and cell culture to delineate the underlying cell and molecular mechanisms. Trainees' research can be conducted with Primary, Secondary, and Associate Mentors at closely collaborating laboratories at the University of Maryland School of Medicine Division of Gerontology, Division of Endocrinology, Diabetes, and Nutrition, Department of Physiology, and School of Nursing and Childrens National Medical Center Research Center for Genetic Medicine. Trainees complete coursework in the basic biology of aging; specific knowledge in exercise, CV, musculoskeletal, metabolic, cell, and molecular biology and physiology; genetics; and biostatistics and research design. We propose to continue this program to fund each of 6 predoctoral trainees for 4 yrs to complete their PhD degrees with high-quality coursework and a dissertation research project that will prepare them for an NIH postdoctoral research fellowship and an eventual academic faculty position with a research program focusing on exercise biology and aging. RELEVANCE (Seeinstructions): This program will support 6 trainees/yr to complete their PhD degrees with a high-quality dissertation research project. The long-term goal is to prepare trainees to pursue high-level NIH postdoctoralresearch fellowships and, eventually, academic faculty positions that focus on research and teaching in the prevention of such major age-associated issues as sarcopenia, obesity, diabetes, hypertension, and CV disease.