Study of Women's Health Across the Nation - Coordinating Center

描述(由申请人提供)：全国妇女健康研究(SWAN)是一项由7个中心、多种族组成的纵向研究，旨在描述更年期过渡期间发生的生理和心理社会变化。斯旺已经积累了十年的关于过渡时期的内分泌学以及其他与中年健康和老龄化相关的因素的数据。随着Swan要求第四次竞争性更新，这项研究本身就提出了从研究更年期转向研究女性衰老的建议。天鹅四号项目开始时参与者的平均年龄为59岁(54岁至65岁)，天鹅四号将跟踪这些妇女完成59岁至70岁的年龄范围。Swan拥有前所未有的能力，将它在中年和更年期过渡期间收集的广泛的生物学、医学、社会、行为和人口统计数据与早期健康状态的积极和不利发展联系起来。SWAN IV的主要目标是：1)确定绝经后(末次月经后2至12年)的内分泌学和症状学特征；2)确定与早期老年相关并可能受到我们在中年研究的因素影响的其他健康结果(如测量的身体表现)；3)了解妇女的中年和绝经过渡经历与随后积极和消极健康结果之间的关系。为了实现这一目标，研究人员建议每年进行一次电话接触，密切跟踪更年期状态、更年期症状和选定的健康事件。此外，建议进行两次面对面的门诊访问，以完成对早期疾病的详细体检措施。SWAN IV的主要主题领域包括1)身体功能；2)骨骼/骨质疏松症；3)认知功能/症状/心理健康；4)心血管。天鹅的新领域包括体能表现和骨关节炎，主要抑郁史，以及颈动脉壁厚度。斯旺将继续监测症状、认知、心血管危险因素、内分泌、骨密度和骨折。SWAN IV将促进我们对与更年期过渡相关的可改变的风险因素如何与亚临床疾病措施和硬结果相联系的理解。这可能导致改进妇女疾病初级预防的战略。 相关性：SWAN汇编了迄今为止最全面的关于妇女从绝经前到绝经后的健康以及生理和心理社会变化的特征的社区样本。特别具有公共卫生重要性的是，SWAN的继续将使这项研究能够增加对这些与更年期相关的变化对随后的健康和与年龄相关的疾病的风险因素的影响的了解。

DESCRIPTION (provided by applicant): The Study of Women's Health Across the Nation (SWAN) is a 7-center multi-ethnic longitudinal study designed to characterize the physiological and psychosocial changes that occur during the menopausal transition. SWAN has amassed ten years of data about endocrinology of the transition and other factors relevant to midlife health and aging. As SWAN requests its fourth competing renewal, the study itself proposes to transition from a study of the menopause to a study of aging in women. The average age of participants at the beginning of the SWAN IV project will be 59 years (54 to 65) and SWAN IV will follow these women through the age range of 59 to 70. SWAN has the unprecedented capability to link the expansive biological, medical, social, behavioral, and demographic data it has collected during mid-life and the menopausal transition to the development of both positive and adverse health states in early oldage. The primary objectives of SWAN IV are to: 1) Characterize the endocrinology and symptomotology of the post-menopause (2 to 12 years after final menses); 2) Ascertain additional health outcomes (such as measured physical performance) that are relevant to the early old age range and that may be affected by the factors that we have studied in mid-life and 3) Understand the relations between the mid-life and menopausal transition experience of women and subsequent positive and negative health outcomes. To accomplish this, the investigators propose annual phone contact to closely track menopausal status, menopausal symptoms and selected health events. In addition, two in-person clinic visits are proposed to accomplish detailed physical measures of early disease. The major thematic areas of SWAN IV include 1) Physical Functioning; 2) Bone/Osteoporosis; 3) Cognitive Function/ Symptoms/ Mental Health and 4) Cardiovascular. New areas for SWAN include physical performance and osteoarthritis, history of major depression, and carotid wall thickness. SWAN will continue to monitor symptoms, cognition, cardiovascular risk factors, endocrinology, bone density and fractures. SWAN IV will advance our understanding of how modifiable risk factors related to the menopause transition are linked to sub-clinical disease measures and hard outcomes. This may lead to improved strategies for the primary prevention of disease in women. RELEVANCE: SWAN has compiled the most comprehensive characterization to date of the health and the physiologic and psychosocial changes of women from pre- to postmenopause in community based samples. Of particular public health importance is that the continuation of SWAN will permit the study to increase understanding of the effects of these menopause-related changes on subsequent health and risk factors for age-related diseases.