Neurological Sciences Academic Development at CNMC.

描述（由申请人提供）：随着儿童神经病学进入一个新时代，迫切需要开发一批新的研究者，他们不仅了解儿童神经疾病的分子基础，而且在转化神经科学方面受过良好培训，以开发基于生物学的疗法并进行转化研究。NSADA培训计划的目标是促进儿童神经学家的基本临床和转化研究技能的发展，鼓励这些有前途的初级教师将精力集中在儿童神经学的重要问题上，并培养一批初级研究人员成为儿科神经学的领导者，专注于多学科的转化研究。我们建议在奖励期间培训3名儿童神经学家，并在培训结束时，期望这些获奖者能够在儿童神经疾病方面进行重要的临床和转化研究，能够在医学院的部门中担任终身职位，并能够成功竞争校外补助金支持。该奖项将侧重于儿童神经学重要领域的培训，包括神经肿瘤学，神经肌肉疾病，神经遗传和神经代谢疾病，发育神经生物学/发育障碍和急性脑损伤/神经保护。在第一个资助周期，CNMC的NSADA计划获得了两名获奖者，并通过创新机制，与CNMC和NINDS的学术办公室合作，能够培养3名优秀的年轻医生，他们正在追求学术事业，并成功地竞争校外资助支持。CNMC NSADA计划在培训年轻医生科学家方面具有丰富的经验，并具有组织良好的计划结构。一批经验丰富的导师已同意参加该计划;导师谁是在培训年轻的医生科学家经验丰富，并已显示出获得独立的校外支持他们的研究能力。他们都拥有完善的实验室，并在CNMC或附属项目中获得终身职位，进一步证实了他们履行导师角色的能力。预计每个获奖者将有一个强大的指导团队，由一位经验丰富的导师领导，并将有显着的保障措施，以确保获奖者的成功。每个获奖者将有一个详细的培训计划，包括一个教学教育计划，这是个性化的，但强调共同的元素，包括培训和负责任的研究，统计设计，创新的分子和神经生理学技术的行为。将为所有候选人提供分子遗传学，细胞成像和细胞神经科学，神经成像，神经心理学以及统计设计和分析的核心实验室课程。该计划将利用一个完善的选择过程，以确定适当的获奖者和导师（导师团队）。CNMC奖学金计划中有强大的潜在候选人;然而，该计划还将在其自身计划之外吸引获奖者，并制定了完善的招聘和保留计划，以提高多样性。CNMC不断增长的研究和学术项目，包括其被授予唯一一家领导CTSA的儿童医院和两所被纳入NEXT联盟的儿科医院之一，也确保了获奖者在NSADA项目中的成功。

DESCRIPTION (provided by applicant): With child neurology entering a new era, there is a critical need to develop a new cohort of investigators who not only understand the molecular underpinnings of childhood neurologic disease, but are also well- trained in translational neuroscience to develop biologically-based therapies and perform translational research. The goals of the NSADA training program, of which we are asking renewal, are to promote the development of the basic clinical and translational research skills of child neurologists, encourage these promising junior faculty members to focus their efforts on important problems in child neurology, and to train a cohort of junior investigators to become leaders in pediatric neurology, focusing on multidisciplinary translational research. We propose to train 3 child neurologists over the period of the award and, at the end of training, expect these awardees to have the skills to perform important clinical and translational research in neurologic conditions o childhood, to be able to assume tenure track positions in medical schools with departments, and to be able to compete successfully for extramural grant support. This award will focus on training in important areas in child neurology including neuro-oncology, neuromuscular disorders, neurogenetic and neurometabolic diseases, developmental neurobiology/developmental disorders and acute brain injury/neuroprotection. Over the first grant cycle, the NSADA program at CNMC was granted two awardees, and through innovative mechanisms, in collaboration with the academic office of CNMC and NINDS, was able to train 3 excellent young physicians who are pursuing academic careers and are successfully competing for extramural grant support. The CNMC NSADA program has experience in training young physician scientists and has a well-organized programmatic structure. A cohort of experienced mentors have agreed to participate in the program; mentors who are experienced in training young physician scientists and have shown the ability to obtain independent extramural support for their research. They all have well-established laboratories and are tenured at CNMC or affiliated programs, further substantiating their ability to perform their mentoring roles. It is expected that each awardees will have a strong mentoring team led by one experienced mentor, and that there will be significant safeguards built into the program to ensure the awardees' success. Each awardee will have a detailed training program, including a didactic educational program which is individualized, but stresses common elements including training and responsible conducts of research, statistical design, and innovative molecular and neurophysiologic techniques. Core laboratory programs in molecular genetics, cellular imaging, and cellular neuroscience, Neuro-imaging, neuropsychology, and statistical design and analysis will be offered to all candidates. The program will utilize a well-developed selection process to both identify appropriate awardees and mentors (mentorship team). There are strong potential candidates in place in the CNMC fellowship program; however, the program will also reach outside its own program to attract awardees and has a well-developed plan for recruitment and retention plan to enhance diversity. The growing research and academic programs at CNMC, including its award of being the only children's hospital to lead a CTSA and one of two pediatric hospitals to be included in the NEXT consortium, also ensures the awardees' success within the NSADA program.