Protein Kinases and Protein Phosphorylation

描述（由申请人提供）：信号转导领域的目标是鉴定和表征作为信号传导途径的一部分从一个分子到另一个分子的通信的生物化学和分子基础。在过去的30年里，这些知识大大提高了对激酶和磷酸化事件如何控制与正常生长和发育相关的所有已知细胞过程的理解。不幸的是，这些途径也通过各种机制被解除管制，当这种情况发生时，各种人类发育障碍和疾病就会出现。在人类基因组中有超过500种蛋白激酶具有调节蛋白磷酸化的潜力，但相对较少被充分表征。在这些基因中，许多现在已知在正常发育和疾病中具有重要功能。由于这些酶在各种生物过程和许多人类疾病中起着中心作用，并且由于蛋白激酶是治疗干预的潜在靶点，因此在确定信息传递的分子基础和受影响的生物过程方面已经做出了巨大的努力。新激酶及其功能的表征可能会揭示更多新的治疗靶点。分子癌症研究经常与激酶和磷酸化研究的进展交织在一起，因为现在已知激酶的改变是几乎所有已知形式的人类癌症中发现的最常见的突变之一。因此，激酶抑制剂在过去50年中已成为最普遍的抗癌药物形式，在过去几年中，每年有数百种新的激酶抑制剂进入临床试验。这是蛋白激酶和蛋白磷酸化竞技场中真正激动人心的时刻。因此，为了使这一科学发现得以进行，该领域的主要科学家之间的信息和思想交流至关重要。自1983年成立以来，FASEB关于“蛋白激酶和蛋白磷酸化”的夏季研究会议（每两年举行一次）一直是信号转导领域的杰出会议之一，为学术界和工业界的研究成果提供了一个首要的交流场所。拟议会议的目标是继续这一令人兴奋和热情的科学交流的传统。

DESCRIPTION (provided by applicant): The goal of the signal transduction field is to identify and characterize the biochemical and molecular basis of communication from one molecule to another as part of a signaling pathway. Over the last 30 years, this knowledge has provided a vastly improved understanding of how kinases and phosphorylation events control all known cellular processes associated with normal growth and development. Unfortunately, these pathways are also deregulated through an assortment of mechanisms, and when this occurs a variety of human developmental disorders and diseases arise. There are over 500 protein kinases in the human genome with the potential to regulate protein phosphorylation, but relatively few are well characterized. Of those that are, many are now known to possess important functions in normal development and disease. Because of the central role these enzymes play in a variety of biological processes and in many human diseases, and because protein kinases are potential targets for therapeutic intervention, a tremendous effort has been made at determining the molecular basis for information transmission and the biological processes affected. The characterization of new kinases and their functions will likely reveal even more novel therapeutic targets. The study of molecular cancer research has often been intertwined with advances in the study of kinases and phosphorylation, as it is now known that alterations in kinases are amongst the most common mutations found across nearly all known forms of human cancer. As a result, kinase inhibitors have emerged as the most prevalent form of anti-cancer agents in the past 50 years, with hundreds of new kinase inhibitors entering clinical trials every year for the past few years. These are truly exciting times in the protein kinase and protein phosphorylation arena. Thus, it is critical that the exchange of information and ideas between the leading scientists in the field occur in order for this scientific discovery o proceed. Since its inception in 1983, the FASEB summer research conference on "Protein Kinases and Protein Phosphorylation" (held biennially) has consistently been one of the preeminent meetings in the field of signal transduction, providing a premier venue for the communication of research findings from both academia and industry. The goal of the proposed conference is to continue this tradition of exciting and enthusiastic scientific exchange.