The Role of Altered Permeability in Bladder Diseases

我们假设有一种统一的机制与急性或慢性因素相关，这些因素破坏了通常保护膀胱的抗渗透屏障。因此，我们认为膀胱通透性增加是许多良性膀胱疾病的根本原因。(1)在膀胱再生过程中，新生器官对尿液的渗透性使愈合和纤维化之间的竞争倾向于纤维化，我们将通过动物模型研究再生膀胱的渗透性降低如何促进愈合。

We hypothesize that there is a unifying mechanism associated with acute or chronic factors that damage the impermeability barrier that normally protects the bladder. Thus, we propose that increased permeability of the bladder is a root cause of many benign bladder diseases. (1) In bladder regeneration, the race between healing and fibrosis is tipped in favor of fibrosis by permeability of the nascent organ to urine, and we will investigate with animal models how decreasing permeability of the regenerating bladder facilitates healing. (2) In IC/PBS, depolarization of sensory nerves and structural changes induced by leakiness underlie that pathology. Comorbidity studies suggest that a reciprocal relationship exists between bowel and bladder such that changes in one induces permeability changes in the other, and animal studies of this reciprocity will reveal mechanisms relevant to clinical populations. Increased permeability may be a factor in OAB as well. We, therefore, plan a clinical study to determine the role of increased permeability in IC/PBS and CPP and LUTS as a function of aging.