Behavioral Interventions and Long Term Outcomes in Juvenile Fibromyalgia Syndrome

描述（由申请人提供）：该职业中期研究者奖申请的具体目标是：1)成功实施一项正在进行的青少年纤维肌痛随机临床试验；2)进行一项前瞻性纵向研究，以确定青少年纤维肌痛儿童患者的长期预后；3)利用候选人在儿科疼痛研究项目中正在进行的和计划中的研究来培训儿科疼痛研究的博士后研究员和初级教师。候选人的规划研究重点是患有慢性疼痛的儿童和青少年的身体和社会心理功能，重点是青少年纤维肌痛综合征-一种非常不了解的慢性疼痛病症，没有基于证据的治疗方法。研究计划包括两个项目：NIAMS资助的多地点随机临床试验（ROl），以测试认知行为治疗儿童和青少年青少年纤维肌痛的疗效，以及青少年纤维肌痛的纵向研究。候选人的未来计划是利用当前项目的发现来开发针对青少年纤维肌痛和其他儿科疼痛状况的最有效的治疗方法。该指导计划旨在培养儿童慢性疼痛临床干预和结果研究领域的未来临床研究者。候选人的计划包括：1)对博士后进行个体化指导，由两项目前资助的临床试验（青少年纤维肌痛的治疗和慢性儿科头痛）、拟议的青少年纤维肌痛纵向研究支持；以及其他正在进行的儿科疼痛的临床和转化研究；2)指导研究员制定他们自己的独立研究计划；3)让研究员参与已建立的关于手稿和拨款写作、临床研究方法和负责任的人体研究行为的教学计划。辛辛那提儿童医院为该奖项提供了一个理想的环境，因为该医院对以患者为导向的研究提供了强有力的机构支持，有一个屡获殊荣的慢性疼痛项目，来自部门数据核心的方法和数据管理问题的支持，以及该机构对儿科患者“改变结果”的承诺。相关性（见说明书）：本研究符合更好地理解和治疗儿童慢性疼痛（青少年纤维肌痛）的公共卫生目标，以及培养下一代儿科疼痛临床和转化研究的临床科学家的目标。

DESCRIPTION (provided by applicant): The Specific Aims of this Midcareer Investigator Award application are to 1) successfully implement an ongoing randomized clinical trial in juvenile fibromyalgia 2) perform a prospective longitudinal study to determine long term prognosis of pediatric patients with juvenile fibromyalgia, and 3) use the candidate's ongoing and planned studies in the Pediatric Pain Research Program to train post-doctoral fellows and junior faculty in pediatric pain research. The Candidate's programmatic line of research focuses on physical and psychosocial functioning of children and adolescents with chronic pain, with an emphasis on juvenile fibromyalgia syndrome - a very poorly understood chronic pain condition for which there is no evidence- based treatment. The Research Plan includes two projects: a NIAMS funded multi-site randomized clinical trial (ROl) to test the efficacy of cognitive behavioral treatment for children and adolescents with juvenile fibromyalgia, and a longitudinal study of outcomes in juvenile fibromyalgia. The candidate's future plans are to use findings from current projects to develop the most effective treatments for juvenile fibromyalgia and other pediatric pain conditions. The Mentoring Plan is to train future clinical investigators in the field of clinical interventions and outcomes research in pediatric chronic pain. The candidate's plan consists of 1) individualized mentoring of postdoctoral fellows supported by two currently funded clinical trials (Treatment of Juvenile Fibromyalgia, and Chronic Pediatric Headaches), the proposed longitudinal study in juvenile fibromyalgia, and other ongoing clinical and translational research studies in pediatric pain 2) mentoring of fellows to develop their own independent research proposals and 3) participation of fellows in established didactic programs on manuscript and grant writing, clinical research methodology and responsible conduct of human research. Cincinnati Children's provides an ideal setting for this award because of the strong institutional support for patient-oriented research, presence of an award winning chronic pain program, support from the Divisional Data Core for methodological and data management issues, and a commitment of the institution to "change the outcomes" for pediatric patients. RELEVANCE (See Instructions): This study meets the public health goal of better understanding and treating a poorly understood chronic pain condition of childhood (juvenile fibromyalgia) along with the goal of training the next generation of clinician-scientists in clinical and translational research in pediatric pain.