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Investigating widespread regulation of gene expression through intron retention

Investigating widespread regulation of gene expression through intron retention
通过内含子保留研究基因表达的广泛调控
批准号:
nhmrc : 1080530
负责人:
Dr Justin Wong
金额:
$24.21万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 2017-12-31

项目摘要

项目成果

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中文摘要
翻译
我们最近发现了一种隐藏的基因调控类型,这种基因调控似乎在包括白血病、黑色素瘤和结肠癌在内的多种癌症中发生了改变。我们将使用分子和计算工具探索这种广泛相关的机制。我们创建了唯一一个能够检测这种调控的计算机程序,现在将通过云计算技术与癌症科学家分享我们的发现。
英文摘要
We recently discovered a hidden type of gene regulation that appears to be altered in diverse cancers including leukaemia, melanoma and colon cancer. We will explore this widely relevant mechanism using molecular and computational tools. We created the only computer program able to detect this type of regulation and will now share our discovery with cancer scientists through cloud computing technology.
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会议论文
Deciphering the role of DNA methylation in the regulation of alternative splicing
  • 批准号:
    nhmrc : 1129901
  • 项目类别:
    Project Grants
  • 资助金额:
    $59.06万
  • 财政年份:
    2017
  • 负责人:
    Dr Justin Wong
  • 依托单位:
Deciphering the role of DNA methylation in the regulation of alternative splicing
  • 批准号:
    nhmrc : GNT1129901
  • 项目类别:
    Project Grants
  • 资助金额:
    $86.55万
  • 财政年份:
    2017
  • 负责人:
    Dr Justin Wong
  • 依托单位:
Investigating the role of aberrant splicing (intron retention) in acute myeloid leukaemia
  • 批准号:
    nhmrc : GNT1128175
  • 项目类别:
    Project Grants
  • 资助金额:
    $113.57万
  • 财政年份:
    2017
  • 负责人:
    Dr Justin Wong
  • 依托单位:
Investigating the role of aberrant splicing (intron retention) in acute myeloid leukaemia
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