Preventing Prematurity and Poor Pregnancy Outcomes Training Grant

描述（申请人提供）：这个新的T-32申请，“预防早产和不良妊娠结局培训补助金”，从新生儿科/儿科系在范德比尔特大学医学院是建立一个博士后培训计划，儿科亚专业研究员的研究和职业重点在（a）发育和围产期生物学，（B）遗传，（c）通过转化、流行病学、质量改进和比较有效性研究，改善出生结果。该计划的长期目标是培养医生科学家和围产期研究的未来领导者，他们将做出职业生涯的贡献，这将对出生结果产生积极影响。具体目标是在儿科专科奖学金培训早期确定有前途的学员，并在合格导师的监督下为他们提供强大的跨学科研究经验，这些导师可以随时获得足够的实验室资源，人口或有不良出生结果风险的母亲和婴儿的数据集。该计划将利用范德比尔特庞大的机构资源，包括范德比尔特CTSA，大量的核心设施，公共卫生硕士和临床研究科学硕士，优质学者计划和范德比尔特循证实践中心。鉴于申请人人数众多，我们建议在第二年和第三年的研究金培训中每年资助两个职位，并承诺在第四年根据需要提供机构资金继续培训。一组有才华的NIH资助的研究人员与成功的指导证明记录已从代表范德比尔特大学独特的研究优势的多个学科选择。该计划的结构化研究培训将灌输解决围产期健康结果关键问题所需的技能和知识。有前途的初级教员被确定为“培训导师”。一个由4名成员组成的指导委员会和一个由发育生物学、围产期健康结局和医生-科学家培训领域的校内和校外专家组成的6名成员咨询委员会将为学员的选择和进展以及整体计划的成功提供指导。

DESCRIPTION (provided by applicant): This new T-32 application, "Preventing Prematurity and Poor Pregnancy Outcomes Training Grant", from the Division of Neonatology/Department of Pediatrics at Vanderbilt University School of Medicine is for the establishment of a postdoctoral training program for pediatric subspecialty fellows with a research and career focus in (a) developmental and perinatal biology, (b) genetic, environmental and biochemical/molecular causes of birth defects, preterm birth and its sequelae and (c) improvement in birth outcomes through translational, epidemiological, quality improvement and comparative effectiveness research. The long-term goals of this program are to develop physician-scientists and future leaders in perinatal research who will make career-long contributions that will positively impact birth outcomes. The Specific Aims are to identify promising trainees early in pediatric subspecialty fellowship training and provide them with a robust, interdisciplinary research experience under the supervision of a qualified mentor with ready access to adequate laboratory resources, populations or datasets of mothers and infants at risk of poor birth outcomes. This program will capitalize on the vast institutional resources at Vanderbilt including the Vanderbilt CTSA, a plethora of core facilities, the Masters in Public Health and Masters of Science in Clinical Investigation, the Quality Scholars Program and the Vanderbilt Evidence-based Practice Center. Given the strong applicant pool, we propose to fund two positions per year in each of the 2nd and 3rd years of fellowship training with commitment of institutional funds for continued training in a 4th year when desired. A talented group of NIH-funded investigators with proven track records of successful mentorship have been chosen from across multiple disciplines representing the unique research strengths of Vanderbilt University. The program's structured research training will instill the skills and knowledge required to address critical issues in perinatal health outcomes. Promising junior faculty have been identified as "mentors-in-training". A 4 member steering committee and a 6-member advisory committee of intramural and extramural experts in the fields of developmental biology, perinatal health outcomes and physician-scientist training will provide guidance on trainee selection and progress and overall program success.