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Cardiomyocyte Proliferation and Ventricular Morphogenesis

Cardiomyocyte Proliferation and Ventricular Morphogenesis
心肌细胞增殖和心室形态发生
批准号：
8657082
负责人：
Henry M Sucov
金额：
$43.7万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
项目状态：
已结题
起止时间：
2002-07-01 至 2016-04-30
来源：
https://reporter.nih.gov/project-details/8657082
关键词：
AccountingAddressAdultBiological AssayBlood VesselsCXCL12 geneCardiac MyocytesCause of DeathCell CountCoculture TechniquesCommunicationCoronaryCouplesDataDevelopmentEmbryoEmbryonic HeartEndocardiumEndothelial CellsEpicardiumErythropoietinFetal LiverGeneticGenetically Engineered MouseGrowthHeartHeart DiseasesHepaticIGF2 geneIn VitroInsulin-Like Growth Factor ReceptorInterleukin-2Knock-outLengthLigandsLiverMitogensModelingMorphogenesisMusMutagenesisMyocardiumNatural regenerationProcessProliferatingReceptor GeneRecruitment ActivityResearchRetinoic Acid ReceptorRoleSignal TransductionSourceSurfaceTestingTimeTissuesTretinoinTubeVascular blood supplyVentricularWestern WorldWorkascending aortabasecardiogenesiscell typechemokinegenetic manipulationin vitro Assayin vivomouse developmentmutantpublic health relevancereceptorreceptor functionrepairedresearch studytissue/cell culturevasculogenesis

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中文摘要
翻译
描述（由申请人提供）：这项工作的主要目的是了解心脏心室腔形成的基础。该项目特别考虑了两个 不同的过程：心肌细胞（心肌细胞）如何在数量上扩大（增殖），以及冠状血管如何形成。这些过程是相互关联的，因为它们受到来自心脏外层（一种称为心外膜的细胞类型）的信号的控制。本项目旨在了解这些信号的作用和机制基础，主要利用基因工程小鼠，胚胎小鼠组织和组织培养细胞进行这项研究。
英文摘要
DESCRIPTION (provided by applicant): The broad objective of this work is to understand the basis of formation of the ventricular chamber of the heart. This project specifically considers two distinct processes: how do cardiac muscle cells (cardiomyocytes) expand in number (proliferate), and how do coronary blood vessels form. These processes are related by virtue of being controlled by signals from the outer layer of the heart, a cell type called the epicardium. This project seeks to understand the role and mechanistic basis of these signals, primarily utilizing genetically engineered mice, explanted embryonic mouse tissue, and tissue culture cells to conduct this research.
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Cardiomyocyte Proliferation and Ventricular Morphogenesis
The complex genetics of heart regeneration
The complex genetics of heart regeneration
Cardiomyocyte heterogeneity and aging
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