Pilot and Exploratory Core

概述。加州大学洛杉矶分校试点探索性研究核心（PESC）的首要任务是促进创新的基础、临床和转化研究，由初级和高级研究人员组成的合作团队进行，这些研究属于加州大学洛杉矶分校的研究主题，“预防弱势群体的疾病和残疾：转化方法”。试点研究将至少满足以下目标之一：a)提供初步研究，为更大规模的基础或临床研究提供信息；B)开发新的基础或临床方法，克服学科进步的关键障碍，从而开辟新的研究途径；C)开发新的多学科研究方法来解决复杂的老年病学研究问题；D)完成基础科学和临床科学的双向翻译；e)确定诊断和/或治疗策略，将发现带到床边。领导。Gail A. Greendale医学博士，医学/老年病学教授，从事更年期、骨质疏松症和身体功能方面的研究，将指导PESC。联合主任将是Rita Effros博士，病理学/实验室医学教授，研究t细胞生物学和免疫衰老。试验过程。PECS将继续其严格的试验选择、监测和开发程序，而不是独立资助的研究奖励。选择包括一个分阶段的过程，包括征求建议书；要求成绩优异的申请人提交完整的申请；经过一系列的评审，最终由。执行委员会、外部顾问委员会及外部遴选委员会。每个飞行员将由PESC联络员监测；监测包括每月报告；与联络员的季度会议；在伊斯兰会议组织研讨会系列上的年度报告；以及对外顾问的年度报告。除了奖励全额试点项目外，PESC还将保持其创新的快速试点项目，该项目为初级教师和高级学员提供高达1万美元的快速周转奖励。快速试点解决了研究开发管道中以前未满足的需求：为谨慎的目的快速获得资金，使初级研究人员的研究能够方便地推进。飞行员。提出了四个完整的试点：1)经验兵团（一种基于社区的代际干预）对弱势少数民族老年人的益处；2)老年人生活在弱势社区是否面临更大的健康风险？3)类风湿关节炎患者HDL功能异常与动脉粥样硬化风险；4)促进p细胞再生的新表观遗传和信号靶点的鉴定。

Overview. The overarching mission of the UCLA Pilot Exploratory Studies Core (PESC) is to promote innovative basic, clinical and translational research, conducted by collaborating teams of junior and senior investigators, that falls within the UCLA's research theme, "Preventing Disease and Disability in Vulnerable Populations: a Translational Approach". Pilot studies will address at least one of the following objectives: a) provide preliminary studies that inform larger basic or clinical investigations; b) develop new basic or clinical methods that surmount critical barriers to progress in a discipline, thus opening new research avenues; c) develop novel multi-disciplinary research approaches to address complex geriatrics research questions; d) accomplish bi-directional basic and clinical sciences translation; and e) identify diagnostic and/or treatment strategies that will bring discoveries to the bedside. Leadership. Gail A. Greendale, MD, Professor of Medicine/Geriatrics, who conducts research in menopause, osteoporosis, and physical functioning, will direct the PESC. The co-director will be Rita Effros, PhD, Professor of Pathology/Laboratory Medicine, who studies T-cell biology and immunosenescence. Pilot Processes. The PECS will continue its rigorous procedures for pilot selection, monitoring, and development \n\o independently funded research awards. Selection consists of a staged process that includes a request for proposals; request for full applications from meritorious applicants; and a series of reviews culminating with final selection by the. Executive Committee, External Advisory Board and External Selection Panel. Each pilot will be monitored by a PESC liaison; monitoring includes monthly reports; quarterly meetings with the liaison; annual presentations at the OAIC Seminar Series; and annual presentations to the External Advisors. In addition to awarding full pilots, the PESC will maintain its innovative rapid pilot program, which makes fast-turn-around awards of up to $10K to junior faculty and advanced trainees. Rapid pilots address a previously unmet need in the research development pipeline: quick access to funding for a discreet purpose, to allow the research of junior investigators to advance expediently. Pilots. Four full pilots are proposed: 1) Benefits of experience corps (a community-based, intergenerational intervention) in vulnerable, older minority adults; 2) Do older adults experience greater health risks from living in disadvantaged neighborhoods?; 3) Abnormal HDL function and atherosclerotic risk in rheumatoid arthritis; 4) Identification of novel epigenetic and signaling targets for promoting p-Cell regeneration.