Inflammation Biomarkers for Diagnosis and Prognosis of Early Stage Lung Cancer

在我们之前的研究基础上，我们发现肺癌诊断患者中循环细胞因子增加，我们正在检查国家肺筛查试验的血浆样本，以寻找细胞因子诊断和预后的标志。这项研究扩展了以往的研究：a)这是一项前瞻性研究，b)良性和恶性病变都是通过低剂量螺旋CT发现的。我们还在检查手术后细胞因子的信号是否下降，并跟踪肿瘤复发，作为一项初步研究，以质疑细胞因子是否可以用来模拟肿瘤复发。这项研究目前正在进行中。

Building on our previous studies where we found increased circling cytokines among patients with a lung cancer diagnosis, we are examining plasma samples from the National Lung Screening Trial for a cytokine diagnostic and prognostic signature. This study extends previous studies as a) this is a prospective study and b) the lesions both benign and malignant, were detected b low dose helical CT. We are also examining whether the signal from cytokines declines following surgery and tracks with tumor recurrence, as a preliminary study to query whether cytokines could be used to model tumor recurrence. This study is currently ongoing.