Development of Networked Implantable Neuroprostheses

描述(申请人提供)：该项目是上肢网络神经假体(NNP)系统的可行性临床研究，以展示为颈椎水平脊髓损伤患者提供抓取和伸展的有效性。NNP系统将以协调的方式电刺激瘫痪的肌肉，以提供抓取和释放、前臂旋前、肘部伸展和肩部/躯干稳定。刺激的模式将由每个受试者通过激活他们的自愿肌肉来控制，通过植入的肌电记录电极来记录。将通过损害、活动和参与度的测量来评估受试者的表现，重点是更独立地进行日常生活活动的能力和日常家庭使用率。我们假设，由于NNP系统的完全植入性，日常使用将得到改善，并且由于NNP系统的模块化和可定制的性质，每个受试者的功能能力都将得到改善，而无论他们开始的功能水平如何。

DESCRIPTION (provided by applicant): This project is a feasibility clinical study of the upper extremity Networked Neuroprosthetic (NNP) System to demonstrate efficacy in providing grasp and reach for individuals with cervical level spinal cord injury. The NNP System will electrically stimulate paralyzed muscles in a coordinated fashion to provide grasp and release, forearm pronation, elbow extension, and shoulder/trunk stabilization. The stimulated patterns will be controlled by each subject through activation of their voluntary musculature, as recorded through implanted myoelectric recording electrodes. Subject performance will be assessed through measures of impairment, activities, and participation, with a focus on the ability to perform activities of daily living more independently and on the rate of daily home use. We hypothesize that daily usage will be improved due to the fully implantable nature of the NNP System and that every subject will improve in their functional ability, regardless of their startin function level, due to the modular and customizable nature of the NNP System.