2014 Biology of Host-Parasite Interactions Gordon Research Conference

描述（由申请人提供）：戈登研究会议（GRC）宿主-寄生虫相互作用是现代寄生虫研究前沿科学交流的最重要场所。该会议自1981年成立以来一直处于该领域的最前沿（最初以寄生虫为标题）。会议将重点关注寄生虫及其与人类相互作用研究的新概念和方法。本次会议将从寄生虫毒力因子和与感染相关的宿主变化的角度具体讨论发病机制。这一组包括大量具有国家和全球影响的重要致病因子。其中包括热带疾病的典型病原体，包括疟疾、昏睡病、恰加斯病、利什曼病和阿米巴痢疾以及许多蠕虫感染。它们一起夺走了世界各地数百万人的生命。寄生虫病在美国也很普遍，包括弓形虫病、隐孢子虫病和毛滴虫病。在美国，每年仅毛滴虫就引起700多万例有症状的感染。弓形虫引起先天性感染。这些疾病中的一些是特别重要的，因为艾滋病和移植患者的机会性感染，并且许多寄生虫（特别是具有孢子样感染阶段的寄生虫）是生物防御关注的，并且在CDC/NIAID病原体列表的附录B中有特征。面对这些疾病，许多重要挑战基本上仍未得到应对。目前还没有针对任何人体寄生虫的有效疫苗，药物治疗的选择也远远不能令人满意。社区高度重视GRC，将其视为获得整个领域概述的机会，了解最新和最令人兴奋的进展，并讨论和制定未来的国家和全球研究议程。这也是学员促进专业发展的重要机会。

DESCRIPTION (provided by applicant): The Gordon Research Conference (GRC) Host-parasite Interactions is the most prominent venue for scientific exchange at the leading edge of modern parasite research. This conference has been consistently at the forefront of the field since its inception in 1981 (originally under the title Parasitism). The conference will focus on new concepts and approaches in the study of parasites and their interaction with humans. This meeting will specifically address mechanisms of pathogenesis both from the viewpoint of parasite virulence factors and also changes in the host associated with infection. This group includes a large number of important disease causing agents with national and global impact. Among these are classical agents of tropical disease including malaria, sleeping sickness, chagas disease, leishmaniasis and amebic dysentery and numerous helminth infections. Together they claim millions of lives around the world. Parasitic disease are also highly prevalent in the U.S. including toxoplasmosis, cryptosporidiosis and trichomiasis. Trichomonas alone causes more than 7 million symptomatic infections each year in the U.S. Toxoplasma causes congenital infection. Some of these diseases are of a particular importance as opportunistic infections in AIDS and transplant patients and a number of parasites (in particular those with spore-like infectious stages) are of biodefense concern and are featured on Appendix B of the CDC/NIAID pathogen list. Numerous important challenges remain largely unmet when facing these diseases. There is currently no effective vaccine available for any human parasite and the options for drug treatment are far from satisfactory. The GRC is highly valued by the community as an opportunity to gain an overview of the entire field, to learn about the most recent and most exciting advances and to discuss and set the national and global research agenda for the future. It is also an important opportunity for trainees to foster their professiona development.