Predoctoral Training in Genetics and Development

描述（由申请人提供）：我们寻求支持继续我们在康奈尔大学遗传学与发育（G&D）的研究生培训项目。遗传学是研究遗传、突变、基因组组织、疾病外显率、基因调控、种群结构和进化机制的一种基础和令人兴奋的方法。这种方法提供了强大的分析工具，可以应用于发育生物学，我们的第二个重点。对于培训师来说，过去的五年尤其多产。我们的培训师的论文包括高影响力的基因组和数量性状分析，以及大量优雅的遗传和发育遗传研究。我们的培训师正在将基本模型系统中获得的结果与人类健康和疾病联系起来，包括糖尿病、癌症综合征、生育和代谢综合征，并将模型用于再生疗法和人类发育。此外，G&D培训师实验室的学生平均每个博士学位完成3.8篇论文，在理解罕见等位基因如何导致人类疾病方面取得了重大进展，并正在解决人类疾病背后的遗传相互作用。我们的项目被普遍认为与其他研究生培训项目和校园培训补助金不同，它开发了一个强大的课程，为校园内的学生和教师提供服务。G&D培训师精力充沛，资金充足（每名培训师每年的直接成本为358,800美元），并且高度协作，是康奈尔大学生命科学四个关键中心的领导者。我们继续吸引优秀的研究生（在竞争激烈的环境中，高质量学生的录取率为44%），并在招收少数民族学生方面加大了努力，并保持了成功。我们继续评估我们的课程，目前正在微调定量生物学和伦理问题和责任的课程。我们不断征求学生对课程各方面的反馈。我们的学生毕业后在遗传学和发育领域就业，并通过课程和指导利用职业建议。在接下来的五年里，随着康奈尔大学生命科学领域即将退休的人员的招聘，以及威尔细胞和分子生物学研究所新的遗传学家的加入，我们预计该领域活跃的年轻培训师将继续增长。这项训练奖助金所提供的财务和计划支持，对我们计划的成长和成功至关重要。只有得到持续的支持，我们才能继续并改进我们培养一流科学家的记录。

DESCRIPTION (provided by applicant): We seek support to continue our program of graduate student training in Genetics and Development (G&D) at Cornell University. Genetics is a fundamental and exciting approach to study the mechanisms that underlie inheritance, mutation, genome organization, disease penetrance, gene regulation, population structure, and evolution. This approach provides powerful analytical tools that can be applied to Developmental Biology, our second emphasis. The last five years has been especially productive for G&D Trainers. Papers from our Trainers include high-impact genomic and quantitative trait analyses in addition to a large number of elegant genetic and developmental genetic studies. Our Trainers are connecting results obtained in basic model systems to human health and disease, including diabetes, cancer syndromes, fertility and metabolic syndromes, and are using models for regenerative therapies and human development. In addition, students in G&D Trainer labs, averaging 3.8 papers per completed Ph.D., are making significant headway in understanding how rare alleles can contribute to disease in the human population and are tackling genetic interactions that underlie human disease. Our program, universally viewed as being distinct from other graduate training programs and training grants on campus, has developed a strong curriculum that serves students and faculty across campus. G&D Trainers are energetic, well-funded ($358,800 in annual direct costs/trainer), and highly collaborative, and are leaders of four critical centers in the Life Sciences at Cornell. We continue to attract outstanding graduate students (44% acceptance rate of high quality students in a very competitive environment) and have increased our efforts and maintained our success at recruiting minority students. We continue to evaluate our curriculum and are currently fine tuning coursework in quantitative biology and ethical issues and responsibilities. We constantly ask for feedback from our students on all aspects of our program. Our students are being employed in genetics and development fields after graduation and are taking advantage of career advice through coursework and mentoring. Over the next five years with hiring in the life sciences at Cornell resulting from impending retirements and the addition of new geneticists in the Weill Institute of Cell and Molecular Biology, we anticipate continued growth of active young trainers in the Field. The financial and programmatic support provided by this training grant has been crucial to the growth and success of our program. Only with continued support will we be able to continue and improve our record of training first- rate scientists.