Training Program on Genetic Variation and Human Phenotypes

项目摘要：范德比尔特遗传变异和人类表型培训计划 支持人类遗传学方面的博士前学生。我们申请资助8名博士后研究生， 资助了两年。这个项目的使命是让这些学生为成功的 在学术、工业或公共服务领域从事人类遗传学工作。我们准备好我们的 学生从注重技能的课堂教学开始，过渡到有经验的- 通过研究和与更有经验的导师的积极合作来进行基于学习的学习。 学生经常接触到人类遗传学研究的领导者通过他们的 合作、研究研讨会以及出席国家和国际会议。这 培训计划取得了广泛的成功，我们的学生取得了出色的生产力 (平均值5.1，范围2-11，最近资助的学生在研究生院期间发表的论文)。学生 人们对人类遗传学培训的热情迅速增加，表现为增加了3倍 进入范德比尔特人类遗传学(HGEN)博士项目的学生人数超过 在过去的5年里。这种日益增长的兴奋在很大程度上源于史无前例的数据 现已向学生开放。以前，它可能需要多年的职业发展才能组装起来 甚至是单一表型的单一大规模队列。然而，随着大型生物库的出现， 有了临床数据，研究生现在可以相对较快地组装队列 适当的培训，这是我们的计划提供的。范德比尔特HGEN项目一直在 走在培养研究生这一新型研究的前沿。带着范德比尔特自己的大- 规模生物库(BioVU)，现在是美国国立卫生研究院“我们所有人”计划的数据和研究中心 位于范德比尔特大学医学中心，我们的研究生已经得到了这两个 在这种新的和突破性的研究中进行实践和正式的教学培训。与 范德比尔特遗传研究所于2015年成立，范德比尔特致力于 用于招聘遗传学和基因组学教师的资源和额外的投资 生物库研究对象的基因分型。我们的研究生都是全面发展的生物学家，大多数 通过范德比尔特大学的跨学科研究生计划(IGP)入学，其余的 定量与化学生物学计划(QCB)。他们以令人惊叹的方式进行研究 各种主题，并以研究生的身份发表在顶级科学期刊上。他们的教育是 显然是赋予他们权力，因为学生本身就是他们自己的主要设计师 范德比尔特内部的合作研究，他们理所当然地感到自己不仅受益于 今天人类遗传学领域的兴奋也在推动着它。

Project Summary: The Vanderbilt Training Program in Genetic Variation and Human Phenotypes supports predoctoral students in human genetics. We request funding for 8 predoctoral students, funded for two years. The mission of this program is to prepare these students for a successful career in human genetics in an academic, industrial, or public service capacity. We prepare our students beginning with skills-focused classroom instruction and transitioning to experienced- based learning through research and active collaboration with more experienced mentors. Students are regularly exposed to leaders in human genetics research through their collaborations, research seminars, and attendance at national and international meetings. This training program has enjoyed broad success, with our students achieving excellent productivity (mean 5.1, range 2-11, publications during graduate school by recently funded students). Student excitement for human genetics training has rapidly increased, demonstrated by a 3-fold increase in the number of students entering the Vanderbilt Human Genetics (HGEN) PhD program over the past 5 years. Much of that increased excitement has grown from the unprecedented data available now to students. Previously, it could take years of career advancement to assemble even a single large-scale cohort of a single phenotype. However, with the advent of large biobanks with clinical data, cohorts can now be assembled relatively quickly by graduate students with the proper training, which our program provides. The Vanderbilt HGEN program has been at the forefront of training graduate students in this new type of research. With Vanderbilt’s own large- scale biobank (BioVU), and now the Data and Research Center for the NIH “All of Us” program located in the Vanderbilt University Medical Center, our graduate students have been getting both hands-on and formal didactic training in this new and groundbreaking type of research. With the establishment in 2015 of the Vanderbilt Genetics Institute, Vanderbilt has committed substantial resources for recruitment of faculty in genetics and genomics and additional investment in genotyping of biobank subjects. Our graduate students are well-rounded biologists, with most matriculating through the Interdisciplinary Graduate Program (IGP) at Vanderbilt and the rest from the Quantitative & Chemical Biology Program (QCB). They conduct research in an amazing variety of topics and publish as graduate students in the top scientific journals. Their education is clearly empowering them, as the students themselves are major designers of their own collaborative research within Vanderbilt, and they rightly feel that they are not just benefitting from the excitement in the field of human genetics today but are also driving it.