Training Program on Genetic Variation and Human Phenotypes

遗传变异和人类表型培训计划

• 批准号: 10420390
• 负责人: Nancy J Cox
• 金额: $ 31.22万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10420390
• 关键词: Genetic Variation; Human; Phenotype; Training Programs

Project Summary: The Vanderbilt Training Program in Genetic Variation and Human Phenotypes supports predoctoral students in human genetics. We request funding for 8 predoctoral students, funded for two years. The mission of this program is to prepare these students for a successful career in human genetics in an academic, industrial, or public service capacity. We prepare our students beginning with skills-focused classroom instruction and transitioning to experienced- based learning through research and active collaboration with more experienced mentors. Students are regularly exposed to leaders in human genetics research through their collaborations, research seminars, and attendance at national and international meetings. This training program has enjoyed broad success, with our students achieving excellent productivity (mean 5.1, range 2-11, publications during graduate school by recently funded students). Student excitement for human genetics training has rapidly increased, demonstrated by a 3-fold increase in the number of students entering the Vanderbilt Human Genetics (HGEN) PhD program over the past 5 years. Much of that increased excitement has grown from the unprecedented data available now to students. Previously, it could take years of career advancement to assemble even a single large-scale cohort of a single phenotype. However, with the advent of large biobanks with clinical data, cohorts can now be assembled relatively quickly by graduate students with the proper training, which our program provides. The Vanderbilt HGEN program has been at the forefront of training graduate students in this new type of research. With Vanderbilt’s own large- scale biobank (BioVU), and now the Data and Research Center for the NIH “All of Us” program located in the Vanderbilt University Medical Center, our graduate students have been getting both hands-on and formal didactic training in this new and groundbreaking type of research. With the establishment in 2015 of the Vanderbilt Genetics Institute, Vanderbilt has committed substantial resources for recruitment of faculty in genetics and genomics and additional investment in genotyping of biobank subjects. Our graduate students are well-rounded biologists, with most matriculating through the Interdisciplinary Graduate Program (IGP) at Vanderbilt and the rest from the Quantitative & Chemical Biology Program (QCB). They conduct research in an amazing variety of topics and publish as graduate students in the top scientific journals. Their education is clearly empowering them, as the students themselves are major designers of their own collaborative research within Vanderbilt, and they rightly feel that they are not just benefitting from the excitement in the field of human genetics today but are also driving it.

项目摘要：范德比尔特遗传变异和人类表型培训计划 支持人类遗传学的博士前学生。我们请求为 8 名博士前学生提供资助， 资助两年。该计划的使命是让这些学生为成功的学习做好准备 以学术、工业或公共服务能力从事人类遗传学的职业。我们准备我们的 学生从以技能为中心的课堂教学开始，过渡到有经验的 通过研究和与更有经验的导师的积极合作进行基础学习。 学生通过他们的研究定期接触人类遗传学研究的领导者 合作、研究研讨会以及出席国内和国际会议。这 培训计划取得了广泛成功，我们的学生取得了出色的生产力 （平均值 5.1，范围 2-11，最近资助的学生在研究生院期间发表的出版物）。学生 人们对人类遗传学训练的热情迅速增加，增加了 3 倍 进入范德比尔特人类遗传学 (HGEN) 博士项目的学生人数超过 过去5年。这种日益增长的兴奋很大程度上来自于前所未有的数据 现在可供学生使用。以前，可能需要数年的职业发展才能组装起来 甚至是单一表型的单一大规模群体。然而，随着大型生物样本库的出现 有了临床数据，研究生现在可以相对快速地组装队列 我们的计划提供适当的培训。范德比尔特 HGEN 计划已在 在这种新型研究中培养研究生的前沿。凭借范德比尔特自己的大型 规模生物样本库 (BioVU)，现在是 NIH“All of Us”计划的数据和研究中心 位于范德比尔特大学医学中心，我们的研究生已经获得了 这种新型突破性研究的实践和正式的教学培训。随着 范德比尔特遗传学研究所于 2015 年成立，范德比尔特大学投入了大量资金 用于招聘遗传学和基因组学教师的资源以及额外投资 生物样本库受试者的基因分型。我们的研究生都是全面发展的生物学家，其中大多数 通过范德比尔特大学的跨学科研究生项目（IGP）入学，其余的则来自 定量与化学生物学计划（QCB）。他们以惊人的方式进行研究 各种主题并以研究生身份在顶级科学期刊上发表文章。他们的教育是 明显地赋予他们权力，因为学生本身就是他们自己的主要设计师 范德比尔特大学内部的合作研究，他们正确地认为他们不仅受益于 当今人类遗传学领域的兴奋点，同时也是其推动力。