Emotions

项目总结（见说明）： 我们将研究额颞叶变性（FTLD）、阿尔茨海默病（AD）和轻度认知障碍（MCI）对社会情绪功能的影响，使用实验室程序，精确评估实际情绪功能的许多方面，包括：（a）情绪反应（对突出挑战和机会的反应类型和程度），（B）情绪调节（能力） 根据情境需求调整情绪反应）和（c）同理心和亲社会行为（识别他人的情绪并对他们的痛苦做出反应）。这些基于实验室的评估测量情绪反应的主要方面，包括：（a）主观情绪体验，（B）情绪表达行为，（c）情绪语言，以及（d）自主和躯体神经系统生理学。这种方法使我们能够确定FTLD和AD中丢失和保留的社会情感功能的特定区域，相互比较以及MCI和对照组。拟议工作的一个特别重点是了解FTLD症状的基础，这些症状对护理人员来说非常麻烦，包括逐渐失去“温暖”和增加社会不适当的行为。我们将使用详细的 分析情绪功能来探索导致这些真实的世界症状的特殊缺陷。描绘特定的缺陷将使我们能够在特定的脑回路（通过结构成像探索）和特定类型的神经病理学（在尸检中探索）中建立强有力的联系。此外，我们将确定社会情绪功能的特定方面的变化与以下因素相关的程度： 通过研究FTLD高发病率家庭中有或没有可疑遗传标记的未受影响的家庭成员，确定FTLD的遗传风险因素。

PROJECT SUMMARY (See instructions): We will study the effects of frontotemporal lobar degeneration (FTLD), Alzheimer's disease (AD), and mild cognitive impairment (MCI) on socioemotional functioning using laboratory procedures that allow for precise assessment of a number of aspects of actual emotional functioning including: (a) emotional reactivity (the type and magnitude of responses to salient challenges and opportunities), (b) emotion regulation (the ability to adjust emotional responses to situational demands) and (c) empathy and prosocial behavior (recognizing others' emotions and responding to their distress). These laboratory-based assessments measure the major aspects of emotional responding, including: (a) subjective emotional experience, (b) emotional expressive behavior, (c) emotional language, and (d) autonomic and somatic nervous system physiology. This approach allows us to identify specific areas of lost and preserved socioemotional functioning in FTLD and AD, compared to each other and to MCI and controls. A particular focus of the proposed work is on understanding the basis of symptoms of FTLD that are very troublesome for caregivers, including a progressive loss of "warmth" and an increase in socially inappropropriate behavior. We will use our detailed analyses of emotional functioning to explore the particular deficits that contribute to these real world symptoms. Delineating specific deficits will enable us to make strong links to damage in specific brain circuits (explored via structural imaging) and particular kinds of neuropathology (explored at autopsy). In addition, we will determine the extent to which changes in particular aspects of socioemotional functioning are related to genetic risk factors for FTLD by studying unaffected family members with and without suspected genetic markers in families with a high incidence of FTLD.