Translational Training in Addiction

描述（由申请人提供）：本提案寻求竞争性更新NIDA T32拨款（DA022981），以支持UAMS培训计划“成瘾转化培训”。该项目最初于2009年获得资助，旨在提供多层次、跨学科的团队科学培训，涵盖转化成瘾研究的分子到基于社区的组成部分。定量和定性数据支持当前培训计划的优秀成果。拟议的项目计划扩展了培训目标，以实现最先进的最佳实践方法，在广泛的学术和非学术劳动力以及基础和临床研究学术环境中培训下一代影响成瘾的科学家。项目评估是基于与七个培训目标相关的进展，包括：(1)发展关于药物使用障碍的科学、临床和社会角色和影响的共享知识；(2)提供成瘾研究职业发展的个性化路径；(3)提供强调跨学科、团队科学、转化研究的学习环境；(4)提供研究伦理和多样性的基础和培训。(5)消除独立性和培训后安置的障碍，(6)监测受训人员和项目进展，(7)培养成瘾的医师-科学家。项目管理和管理将通过项目主管、指导委员会和治理委员会的协调互动来完成。请支助四个级别的受训人员：3名博士预科生、4名博士后和4名医科学生暑期实习生。这将得到PGY3精神病学住院医师的机构支持。项目范围和轨道选择性教学将支持跨学科的T0（分子靶标识别）-T4（实施科学）转化研究培训机会，在广泛的学术和政府成瘾研究环境中强调学员-学员和学员-教师的互动。与职业发展里程碑相关的培训生和项目的成功将被定期监测和评估。职业发展的障碍将通过该计划的“独立之路”部分来解决。重要的，多层次的机构承诺和资源支持该计划的价值和持续的成功。由受训人员领导的社区外联部分将教育和动员地方和州社区参与解决吸毒成瘾问题。基于3年多的项目经验，UAMS的NIDA T32培训项目已经完成了其最初的目标，即有效培训人口多样化和道德意识强的成瘾研究人员，并将学员安置在有竞争力的博士后和教员学术职位上，同时影响培训医生对成瘾研究的认识和欣赏。未来计划寻求在这一成功的基础上，扩大与成瘾问题解决相关的临床转化研究的范围和影响。

DESCRIPTION (provided by applicant): This proposal seeks competitive renewal of a NIDA T32 grant (DA022981) to support the UAMS training program "Translational Training in Addiction." Initially funded in 2009, the program is designed to provide multi-level, transdisciplinary, team science training that spans the gamut of the molecular to community- based components of translational addiction research. Quantitative and qualitative data support the excellent outcomes of the current training plan. The proposed program plan extends the training goals to accomplish a state-of-the-art best practice approach to training the next generation of impacting addiction scientists across a broadening academic and non-academic workforce and basic and clinical research academic settings. Program evaluation is based on progress related to seven training objectives including (1) develop a shared knowledge of the scientific, clinical, and societal roles and impact of drug use disorders, (2) provide an individualized path of addiction research career development, (3) provide learning environments emphasizing interdisciplinary, team science, translational research, (4) provide grounding and training in research ethics and diversity, (5) remove barriers to independence and post-training placement, (6) monitor trainee and program progress, and (7) develop addiction physician-scientists. Program administration and management would be accomplished by coordinated interactions of the program Director, Steering Committee, and Governance Committee. Support is requested for four levels of trainees: 3 predoctoral, 4 postdoctoral, and 4 medical student summer interns. This will be complemented by the institutional support of a PGY3 psychiatry resident. Program-wide and track-selective didactics would support interdisciplinary T0 (molecular target identification)-T4 (implementation science) translational research training opportunities in broad academic as well as government addiction research settings emphasizing trainee-trainee and trainee-faculty interactions. Trainee and program success relative to career development milestones would be regularly monitored and evaluated. Barriers to career development would be addressed by a Path to Independence component of the program. Significant, multi- level institutional commitment and resources support the value and continued success of the program. A trainee-led Community Outreach component would educate and engage the local and state communities in addressing the problems of drug addiction. Based on 3+ years of program experience, the NIDA T32 training program at UAMS has accomplished its initial goals of effectively training demographically diverse and ethically conscious addiction researchers and placing trainees in competitive postdoctoral and faculty academic positions, as well as influencing the awareness and appreciation of addiction research by training physicians. The going forward plan seeks to build on this success and extend the scope and impact of clinical translational research related to addiction problem solving.