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BIOMARKER CORE

BIOMARKER CORE
生物标记核心
批准号：
8601648
负责人：
Robert A Rissman
金额：
$21.7万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8601648
关键词：
AccountingAlzheimer&aposs DiseaseAmyloid beta-ProteinApolipoprotein EApplications GrantsBiologicalBiological AssayBiological MarkersCatalogingCatalogsClinical TrialsCognitiveComplementComplexConfidentialityDNADataDrug KineticsEducational process of instructingFloorGenotypeGoalsGrantHigh Pressure Liquid ChromatographyImmunoassayInterventionLaboratoriesMeasurementMeasuresMedicalMethodologyMonitorPatientsPharmaceutical PreparationsPlasmaPlayProceduresProtein AnalysisProteinsProtocols documentationQuality ControlResearchResearch InfrastructureResearch PersonnelResearch Project GrantsResearch ProposalsResourcesRoleSafetySamplingServicesSiteSpecimenSystemTechnical ExpertiseTimeTrainingamyloid peptidebasecompliance behaviorcooperative studyexperiencegenetic analysisinstrumentmedical schoolsmeetingsneuroimagingnovelpre-clinicalscreeningsuccesstau Proteinstau-1

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相关文献

中文摘要
翻译
在之前的赠款周期中，ADCS在生物标记物测量方面并没有发挥重要作用；载脂蛋白E(ApoE)基因的分析以及血浆和脑脊液中淀粉样多肽和tau蛋白的测量都被分包给公司或外部学术实验室。然而，生物标记物测量的重要性稳步增长，部分原因是阿尔茨海默病神经成像倡议的成功。对存储的ADCS样本的请求数量不断增加，并且 ADCS调查人员对生物标记物测量的要求不断增加。为了满足这些需求，我们在2008年底建立了一个生物标记核心，位于加州大学圣迭戈分校医学院医学教学设施大楼的3楼。
英文摘要
In previous grant cycles, the ADCS has not played a major role in biomarker measurement; assays for Apolipoprotein E (ApoE) genotype, and for plasma and CSF measurement of amyloid peptides and tau proteins have been subcontracted to companies or external academic labs. However, the importance of biomarker measurement has grown steadily, in part due to the success of the Alzheimer's Disease Neuroimaging Initiative. There have been an increasing number of requests for stored ADCS samples, and increasing requests for biomarker measurement from ADCS investigators. To meet these needs, in late 2008, we established a Biomarker Core which is located on the 3rd floor of the Medical Teaching Facility building at UCSD School of Medicine.
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