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IGF::OT::IGF "HUMANIZED MOUSE MODELS FOR HIV THERAPEUTICS DEVELOPMENT"

IGF::OT::IGF "HUMANIZED MOUSE MODELS FOR HIV THERAPEUTICS DEVELOPMENT"
IGF::OT::IGF“用于艾滋病治疗开发的人性化小鼠模型”
批准号：
9004371
负责人：
Cheryl Stoddart
金额：
$199.76万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
项目状态：
已结题
起止时间：
2013-12-06 至 2015-12-05
来源：
https://reporter.nih.gov/project-details/9004371
关键词：
Animal ModelClinical ResearchComplementContractsDataDrug EvaluationHIVIn VitroNational Institute of Allergy and Infectious DiseasePharmaceutical PreparationsPhasePrevention strategyProcessResearch PersonnelResearch SupportResourcesTherapeuticTimeTranslationsdrug discoveryin vitro activityin vivomouse modelnonhuman primateprogramstherapeutic developmenttool development

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中文摘要
翻译
这项计划将通过提供一份在小动物模型上评估潜在HIV疗法的合同来支持NIAID DAIDS药物发现和评估计划。拟议的小鼠模型提供了从体外研究到成本更高的非人类灵长类研究和早期临床研究的桥梁。
英文摘要
This initiative will support NIAID DAIDS drug discovery and evaluation programs by providing a contract to evaluate potential HIV therapeutics in small animal models. The proposed mouse models provide a bridge from in vitro studies to more costly non-human primate studies and early-phase clinical studies.
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会议论文
Single-chain antibodies to block HIV transcription and prevent reactivation from latently infected resting CD4+ T cells
Inhibition of heat shock protein 90 for sustained remission of HIV from persistent tissue reservoirs
HUMANIZED MOUSE MODELS FOR HIV THERAPEUTICS DEVELOPMENT
Heat shock protein 90 and HIV persistence
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