Investigation of a new platelet contractile mechanism regulating thrombus stability

血小板是一种小血细胞，可以形成凝块来止血。我们发现了一种新的收缩过程，可以使血块中的血小板紧密堆积，使血块在血流中避免脱离。我们将研究这一过程，并探索其抑制可能提供一种新的方式来疏松凝块，促进它们的清除。这些研究将为血栓稳定性提供新的见解，并可能为血栓溶解药物的输送提供临床益处。

Platelets are small blood cells that form clots to stop bleeding. We have found a new contraction process that causes tight packing of platelets in a clot, enabling the clot to avoid detachment under blood flow. We will study this process and explore the possibility that its inhibition may provide a new way in which to loosen clots, promoting their removal. These studies will provide new insight into clot stability, and may provide clinical benefit in the delivery of clot dissolving agents .