Center for AIDS Research

描述（由申请人提供）：本提案是宾夕法尼亚大学艾滋病研究中心（CFAR）的竞争性更新，该中心包括宾夕法尼亚大学、费城儿童医院和Wistar研究所。宾夕法尼亚大学艾滋病研究中心将这些机构的艾滋病研究人员联系起来，致力于实现美国国立卫生研究院艾滋病研究中心使命宣言中规定的目标，并在宾夕法尼亚大学/CHOP/Wistar校园促进跨学科的艾滋病研究活动。CFAR的具体目标是：(1)为创新性、跨学科、合作性和转化性艾滋病毒/艾滋病研究提供领导，创建和支持基础设施；(2)确定艾滋病毒/艾滋病研究的新科学领域；(3)创建、赞助和促进不同科学领域的教育和培训项目，并在指导下一代艾滋病毒/艾滋病研究人员方面发挥领导作用；(4)开展和协调社区外展工作；(5)促进社区中心之间的协作和协同活动和研究项目，以扩大社区中心的附加价值；(6)与美国以外的机构和调查人员建立伙伴关系，加强发展中国家和受艾滋病影响最严重的资源有限地区的艾滋病毒/艾滋病研究和指导能力。宾夕法尼亚大学CFAR包括四个研究领域：病毒学/发病机制、临床/治疗学、免疫学/疫苗和行为与社会科学，并创建了三个前瞻性和动态的科学工作组，以满足艾滋病毒/艾滋病研究中关键的新兴科学优先事项和机会。该中心由James Hoxie博士指导，Ronald Collman博士共同指导，由执行委员会管理，并由内部咨询委员会和外部咨询委员会提供意见。CFAR有一个发展核心和七个共享资源核心：临床、病毒/分子、免疫学、行为与社会科学、生物统计学与数据管理。非人类灵长类动物和国际。这些核心为艾滋病毒/艾滋病研究提供独特的服务，这些服务是校园、领导和教育领域其他地方无法提供的。该中心仍然致力于发展一项创造性的、全面的、跨学科的艾滋病研究计划，该计划与宾夕法尼亚大学、CHOP和Wistar的研究和教育任务充分结合，并致力于应对艾滋病流行病的持续挑战。

DESCRIPTION (provided by applicant): This proposal is a competing renewal for the Penn Center for AIDS Research (CFAR), which includes the University of Pennsylvania, The Children's Hospital of Philadelphia, and The Wistar Institute. The Penn CFAR links HIV/AIDS investigators at these institutions and is committed to goals laid out in the NIH CFAR mission statement and fostering interdisciplinary HIV/AIDS research activities on the Penn/CHOP/Wistar campus. The CFAR's Specific Aims are to: (1) provide leadership that creates and supports infrastructure for innovative, interdisciplinary, collaborative, and translational HIV/AIDS research: (2) identify new areas of scientific opportunity in HIV/AIDS research; (3) create, sponsor and facilitate educational and training programs across diverse scientific areas and play a leadership role in mentoring the next generation of HIV/AIDS investigators; (4) conduct and coordinate community outreach efforts: (5) promote collaborative and synergistic activities and research programs between CFARs that extend the added value of individual CFARs; and (6) develop partnerships with institutions and investigators outside the U.S. that strengthen capacity for HIV/AIDS research and mentoring in developing countries and resource limited settings most affected by the AIDS pandemic. The Penn CFAR includes four Research Areas: Virology/ Pathogenesis, Clinical/Therapeutics, Immunology/Vaccine, and Behavioral & Social Sciences, and has created three forward-looking and dynamic Scientific Working Groups to meet key emerging scientific priorities and opportunities in HIV/AIDS research. The Center is directed by Dr. James Hoxie, co-directed by Dr. Ronald Collman and governed by an Executive Committee with input from an Internal Advisory Board and External Advisory Committee. The CFAR has a Developmental Core and seven Shared Resource Cores: Clinical, Viral/Molecular, Immunology, Behavioral & Social Sciences, Biostatistics & Data Management. Nonhuman Primate, and International. These Cores provide unique services for HIV/AIDS research that are not available elsewhere on campus, leadership and education. The Center remains committed to developing a creative, comprehensive, and interdisciplinary AIDS research program that is fully integrated with the research and educational missions of Penn, CHOP and Wistar and dedicated to meeting the ongoing challenges of the AIDS pandemic. RELEVANCE: This CFAR will build on the success and strengths of its three previous funding cycles to 1) provide strong, experienced, and proactive leadership; 2) contribute to a rich environment of interdisciplinary HIV/AIDS science; 3) develop and lead new initiatives in cutting-edge areas that address the NIH Strategic Plan for HIV research; and 4) foster collegial and collaborative relationships among its investigators.