The Effects of Mood on Functional Brain Connectivity in Low Back Pain Patients du

描述（由申请人提供）：本次申请的总体目标是进一步了解慢性疼痛的神经机制。最近的研究表明，与健康对照组相比，慢性疼痛患者在静息状态下，默认模式网络（DMN）（一组与自由思维相关的大脑区域）的功能连通性异常[5,12,14]。这些群体差异归因于疼痛处理的机制，然而，这一结论存在许多潜在的混淆。参与者通常被指示不要考虑任何特别的事情，导致不标准化的思维过程，从而导致数据解释的模糊性。然而，很少有研究调查参与者的特定行为或认知状态，如情绪或对临床疼痛的关注增加，是否有助于这种非典型连接。因为消极情绪已经被假设为增加个体对躯体感觉b[48]的注意，这些神经过程在慢性疼痛体验中可能存在联系。在慢性疼痛的静息状态下，这些精神状态如何影响大脑活动还需要更多的研究[8,9,10]。这项工作将试图在这种范式中分解某些行为变量和大脑活动之间的关系。本研究的具体目的是：(1)研究积极情绪和与疼痛相关的消极情绪对DMN功能连通性的影响；(2)研究静息状态下与疼痛相关的注意和情感神经过程之间的时间关系。通过本研究的发现，我们希望为解释慢性疼痛患者的静息状态数据提供有用的信息。此外，我们希望解开临床疼痛感知中注意和情感过程的时间关系，这将有助于为治疗发展提供信息。

DESCRIPTION (provided by applicant): The overall goal of this application is to further knowledge about the neural mechanisms of chronic pain. Recent studies have shown that patients with chronic pain have abnormal functional connectivity of the default mode network (DMN) [5,12, 14], a group of brain regions associated with freethinking, compared to healthy controls during resting-state. These group differences have been attributed to mechanisms of pain processing, however there are a number of potential confounds to this conclusion. Participants are typically instructed not to think about anything in particular, leading to unstandardized thought processes and, consequently, ambiguity in data interpretation. Few studies, however, have examined whether a participant's specific behavioral or cognitive state, such as mood or increased attention to clinical pain, contributes to this atypical connectivity. Because negative mood has been hypothesized to increase individuals' attention to somatic sensations [48], it is possible that there is a relationship between these neural processes in the experience of chronic pain. More research is needed to examine how these mental states influence brain activity during resting-state in the experience of chronic pain [8, 9, 10]. The proposed work will attempt to decompose the relationship between certain behavioral variables and brain activity during this paradigm. The Specific Aims of this NRSA are to 1) examine the effects of positive and pain-related negative mood on functional connectivity of the DMN and 2) examine the temporal relationship between pain-related attentional and affective neural processes during resting-state. With the findings from this research, we hope to provide useful information to the interpretation of resting-state data in chronic pain patients. Additionally, we hope to disentangle the temporal relationship of attentional and affective processes in the perception of clinical pain, which will help inform treatment development.