Measuring the Impact of Racism-Induced Medical Mistrust on Placebo Analgesia.

项目摘要 这个为期五年的K23指导职业发展奖的总体目标是提供关键的研究， 职业发展机会，这将有助于候选人的长期职业目标是一个领先的 疼痛治疗反应的神经心理社会机制专家，特别是针对服务不足的种族/民族 组拟议的K23活动将建立在候选人在身心疼痛干预方面的背景之上， 情感疼痛机制，并通过完成研讨会，在线静息状态功能磁共振成像方法 在以下领域的课程、导师会议、研讨会和会议：[1]疼痛差异，[2] 社区参与研究，[3]安慰剂镇痛，[4]基于任务的功能磁共振成像。候选人已经集合了 一个杰出的团队共同导师与专业知识的疼痛差异（主要导师博士克劳迪娅坎贝尔）， 社区参与研究（共同导师Michele Evans博士），安慰剂镇痛（共同导师Luana Colloca博士）， 和基于任务的功能磁共振成像（共同导师劳伦阿特拉斯博士）谁将监督她的进展。通过K23学习的技能 职业发展计划将实际应用于完成一个研究项目， 种族主义引起的医疗不信任（即，对医疗保健系统的不信任， 结构和人际种族主义），安慰剂镇痛（即，神经心理学引起的疼痛缓解 对背景线索的反应），以及生活在美国社会文化中的黑人成年人的伴随大脑活动 环境。将使用针对fMRI环境的完善方案诱导安慰剂镇痛。此外，本发明还 该项目将是第一个收集关于安慰剂可接受性的信息（即，作为疼痛接受安慰剂 治疗），特别是在黑人成年人中，并将询问文化上的反应因素，可以帮助提高 安慰剂镇痛。该项目的结果将提供关键的试点数据，以支持大规模赠款 提交旨在优化居住在美国的黑人成年人的安慰剂镇痛干预。此夕h 完成职业发展计划将使候选人获得必要的技能，资源， 社区伙伴关系，以建立和维护一个独立的研究计划，使用最先进的 改善服务不足种族/民族群体疼痛治疗结果的方法。

PROJECT SUMMARY The overall goal of this five-year K23 Mentored Career Development Award is to provide critical research and career development opportunities that will facilitate the candidate’s long-term career goal of being a leading expert in neuropsychosocial mechanisms of pain treatment responses, particularly for underserved racial/ethnic groups. The proposed K23 activities will build on the candidate’s background in mind-body pain interventions, affective pain mechanisms, and resting-state fMRI methods through the completion of workshops, online coursework, mentor meetings, seminars, and conferences in the following areas: [1] pain disparities, [2] community-engaged research, [3] placebo analgesia, and [4] task-based fMRI. The candidate has assembled an outstanding team of co-mentors with expertise in pain disparities (primary mentor Dr. Claudia Campbell), community-engaged research (co-mentor Dr. Michele Evans), placebo analgesia (co-mentor Dr. Luana Colloca), and task-based fMRI (co-mentor Dr. Lauren Atlas) who will oversee her progress. Skills learned through the K23 career development plan will be practically applied in the completion of a research project examining the association between racism-induced medical mistrust (i.e., mistrust of healthcare systems due to the effects of structural and interpersonal racism), placebo analgesia (i.e., pain relief resultant from neuropsychological responses to contextual cues), and concomitant brain activity among Black adults living in the US sociocultural milieu. Placebo analgesia will be induced using a well-established protocol for the fMRI environment. Further, this project will be the first to collect information about placebo acceptability (i.e., admissibility to placebo as pain treatment) specifically among Black adults and will query for culturally responsive factors that can help boost placebo analgesia. Results from this project will provide critical pilot data that will support a large-scale grant submission aiming to optimize placebo analgesia interventions for US-residing Black adults. Further, the completion of the career development plan will give the candidate the necessary skills, resources, and community partnerships to build and maintain an independent program of research using state-of-the-art methods to improve pain treatment outcomes for underserved racial/ethnic groups.