Investigation of regulators that control the pro-survival molecule MCL1 and its stabililty in lymphoma and myeloma cells
Investigation of regulators that control the pro-survival molecule MCL1 and its stabililty in lymphoma and myeloma cells
控制促生存分子 MCL1 的调节因子及其在淋巴瘤和骨髓瘤细胞中的稳定性的研究
批准号：
nhmrc : GNT1075151
负责人：
Dr Michael Low
金额：
$13.78万
依托单位国家：
澳大利亚
项目类别：
Postgraduate Scholarships
财政年份：
2014
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2014-01-01 至 --
中文摘要
翻译
B细胞恶性肿瘤很常见，在许多情况下会导致死亡。BCL-2家族蛋白MCL-1已被证明在许多B细胞恶性肿瘤中过度表达。然而，MCL-1在这些癌症中的调节和生物学作用在很大程度上仍不清楚。我们的目标是确定在转录和蛋白质水平上控制癌细胞MCL-1表达调控的机制，从而确定新的治疗靶点。
英文摘要
B cell malignancies are common and in many cases result in mortality. The BCL-2 family protein MCL-1 has been shown to be over-expressed in many B cell malignancies. However, the regulation and biology of MCL-1 in these cancers remains largely unknown. We aim to define mechanisms that control regulation of MCL-1 expression in cancer cells at the transcriptional and protein level and hence identify new therapeutic targets.
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