Variations in Hip Morphology: Frequency and Impact on Osteoarthritis Outcomes

描述（由申请人提供）：该候选人是一名风湿病学家，具有临床研究和流行病学方法的基础，对应用于骨关节炎（OA）的新型成像技术有浓厚兴趣。候选人的长期职业目标是成为一名独立资助的学术临床医生和科学家，广泛研究OA，特别强调OA的先进成像和多关节参与。候选人的短期职业目标是：1)设计髋关节形态（包括股髋臼撞击[FAI]和髋关节形状的放射学评估方案并获得实践经验；2）获得先进流行病学和统计方法的专门教学培训；3)学习与其他大型正在进行的队列合作；4)收集数据，建立网络，并在研究中进行研究。并积累必要的出版记录，以竞争独立资助，5)在负责任的研究行为方面获得额外的培训。建议的研究计划、职业发展活动、指导计划、顾问小组和机构环境都非常适合帮助申请人实现这些目标。提出这项研究的基本原理是，了解髋关节形状改变（包括FAI）的频率和临床影响，以及这种改变对OA发展的影响，对于髋关节OA的诊断和治疗干预的知情政策和临床决策至关重要。在Aim 1中，PI将评估FAI在大型人群队列中的放射学表现的患病率，在Aim 2中将确定这些表现与经过验证的临床结果之间的关联。目的3将允许PI确定髋关节形态（通过FAI或主动形状模式）是否预测放射事件或症状性髋关节结局。这项提议的预期结果将是提高对髋关节骨关节炎发展中髋关节形态学的患病率和临床重要性的认识。为了支持候选人的职业发展，她将学习高级数据分析方法和研究伦理方面的课程，以及专业成像方法和解释方面的实践培训。咨询团队包括具有广泛专业知识的多学科合作者（Renner, Schwartz， DeVellis和Helmick）以及国际公认的独立资助的OA流行病学专家（Jordan）和OA成像和形状评估专家（Kraus， Lane和Aspden），他们将指导Nelson博士的研究和职业发展。研究环境将提供一个富有成效的、合议的、合作的氛围，在这种氛围中，纳尔逊博士可以追求她的研究和培训目标。

DESCRIPTION (provided by applicant): The candidate is a rheumatologist with a foundation in clinical research and epidemiologic methods, and a strong interest in novel imaging techniques as applied to osteoarthritis (OA). The candidate's long-term career goal is to become an independently funded, academic clinician-scientist, with a broad research focus on OA, and particular emphasis on advanced imaging and multiple joint involvement in OA. The candidate's short- term career goals are to 1) design a protocol for and gain practical experience with radiographic estimates of hip morphology (including femoroacetabular impingement [FAI], and hip shape by active shape models), 2) obtain specialized didactic training in advanced epidemiologic and statistical methods, 3) learn to collaborate with other large ongoing cohorts, 4) collect data, establish networks, and amass the necessary publication track record needed to compete for independent funding, and 5) obtain additional training in the Responsible Conduct of Research. The proposed research plan, career development activities, mentorship plan, advisory panel, and institutional environment are well suited to assist the applicant in achieving these goals. The rationale for the proposed research is that knowledge of the frequency and clinical impact of alterations in hip shape (including FAI), and the effects of such alterations on the development of OA, is essential to allow informed policy and clinical decisions regarding diagnostic and therapeutic interventions for hip OA. In Aim 1, the PI will assess the prevalence of radiographic findings of FAI in a large population-based cohort, and in Aim 2 will determine associations between these findings and validated clinical outcomes. Aim 3 will allow the PI to determine whether hip morphology (by FAI or active shape modes) predicts incident radiographic or symptomatic hip outcomes. The expected result of this proposal will be an improved knowledge of the prevalence and clinical importance of hip morphology in the development of hip OA. To support the candidate's career development, she will pursue coursework in advanced data analysis methods and research ethics, along with practical training in specialized imaging methods and interpretation. The advisory team, which includes multi-disciplinary collaborators with a wide range of expertise (Renner, Schwartz, DeVellis, and Helmick) as well as internationally-recognized, independently-funded investigators with expertise in OA epidemiology (Jordan) and imaging and shape assessments in OA (Kraus, Lane, and Aspden), will guide Dr. Nelson's research and career development. The research environment will provide a productive, collegial, and collaborative atmosphere in which Dr. Nelson can pursue her research and training goals.