Diverse Drug Lead Compounds from Bacterial Symbionts in Philippine Mollusks

描述(由申请人提供)：团体计划摘要：菲律宾软体动物共生生物BG(PMS-ICBG)利用菲律宾巨大的生物多样性，发现治疗细菌感染、寄生虫感染、疼痛和其他神经疾病以及癌症的新药，这些疾病在菲律宾和美国都是严重的健康问题。菲律宾共和国代表着一个独特的联系：异常的生物多样性、人口稠密与紧迫的社会需求、随之而来的迫切的保护需求以及政府对教育和技术的承诺，以利用国家的人力和自然资源，以实现可持续的未来。我们的重点是软体动物及其微生物共生体；软体动物是海洋动物中最多样化的群体之一，它们相关的细菌代表着一个未被探索的化学多样性宝库。PMS-ICBG将利用我们对软体动物共生体与其宿主之间相互作用的日益加深的了解来发现最新和最有用的分子。该项目将记录和描述菲律宾软体动物的生物多样性，并支持为保护菲律宾生物多样性奠定基础的培训和基础设施。该项目由俄勒冈健康与科学大学海洋微生物学家Margo HayGood与菲律宾大学迪里曼海洋天然产物化学家Gisela Concepcion、犹他大学生物化学家Baldomero Olivera和天然产品化学家兼生物化学家Eric Schmidt、自然科学院Drexel大学软体病学家Gary Rosenberg、东北大学海洋微生物学家Daniel Distel和塔夫茨医学中心寄生虫学家Roberta O‘Connor共同领导。

DESCRIPTION (provided by applicant): Group Plan Summary: The Philippine Mollusk Symbiont ICBG (PMS-ICBG) harnesses the vast biodiversity of the Philippines to discover new drugs to treat bacterial infections, parasitic infections, pain and other neurological conditions and cancer, all of which are serious health problems in both the Philippines and the United States. The Republic of the Philippines represents a unique nexus of exceptional biodiversity, dense human population with pressing societal needs, consequent urgent need for conservation, and government commitment to education and technology to harness national human and natural resources for a sustainable future. Our focus is mollusks and their microbial symbionts; mollusks are one of the most diverse groups of marine animals, and their associated bacteria represent an unexplored trove of chemical diversity. The PMS- ICBG will use our increasing understanding of the interactions between mollusk symbionts and their hosts to discover the most novel and useful molecules. The project will document and describe Philippine mollusk biodiversity and support training and infrastructure that provide the foundation for conservation of Philippine biodiversity. The project is led by Margo Haygood, marine microbiologist, Oregon Health & Science University in association with Gisela Concepcion, marine natural products chemist, University of the Philippines, Diliman; Baldomero Olivera, biochemist and Eric Schmidt, natural products chemist and biochemist, both of University of Utah, Gary Rosenberg, malacologist, of the Academy of Natural Sciences, Drexel University, Daniel Distel, marine microbiologist, Northeastern University, and Roberta O'Connor, parasitologist, Tufts Medical Center.