The Chernobyl Tissue Bank - Coordinating Center

描述(申请人提供)：1986年切尔诺贝利核电站事故对人类健康唯一明确的辐射影响是儿童或青春期早期暴露的人患甲状腺癌的增加。切尔诺贝利组织银行(CTB：www.ChernobylOrganebank.com)成立于1998年，目的是方便国际科学家获取切尔诺贝利事故后诊断为甲状腺肿瘤的患者的生物标本和数据。它已经向全球研究界发布了超过11,252种生物标本。CTB与东欧研究所合作，收集、记录和存储患者的组织和血液样本。东欧研究所是治疗甲状腺癌的机构。甲状腺癌通常很小，患者需要大部分组织才能做出准确的诊断。然而，剩余的材料可以是 在征得患者同意后，用于研究研究。协调中心与东欧研究所合作，从这些珍贵的样本中提取分析物(如RNA和DNA)，以便许多使用不同技术的不同研究项目可以获得同一患者的样本。除了发布样本，CTB还使用世行整理项目的研究数据，并将这些数据提供给未来的研究人员，这丰富了来自同一患者的剩余样本的价值，并使理解甲状腺癌涉及的机制的综合或“系统”生物学方法成为可能。甲状腺癌在世界范围内的发病率正在上升，从这个项目中继续发布样本和整理研究和临床结果数据所获得的信息，将在长期识别哪些患者有复发和死于疾病的风险。CTB处于人类组织研究银行的前沿，目前的提议旨在扩大银行中存储的样本和数据的使用，以促进正在进行的和未来的研究项目，包括那些由NIH资助的项目。

DESCRIPTION (provided by applicant): The only unequivocal radiological effect of the Chernobyl Nuclear Power Plant accident in 1986 on human health is the increase in thyroid cancer in those exposed in childhood or early adolescence. The Chernobyl Tissue Bank, (CTB: www.chernobyltissuebank.com), was established in 1998 to facilitate access by international scientists to biospecimens and data from patients diagnosed with thyroid tumors post Chernobyl. It has already released more than 11,252 biospecimens to the worldwide research community. The CTB works with the Eastern European Institutes, where patients with thyroid cancer are treated, to collect, document and store samples of tissue and blood from patients. Thyroid cancers are usually small, and much of the tissue is required for an accurate diagnosis for the patient. However, leftover material can be used, with the patient's consent, in research studies. The Coordinating Centre works with the Eastern European Institutes to extract analytes (such as RNA and DNA) from these precious samples, so that many different research projects using different techniques can get access to samples from the same patient. In addition to release of samples, the CTB also collates research data from projects using the Bank, and makes these available to future researchers, which enriches the value of remaining samples from the same patient and enables an integrated or "systems" biology approach to understanding the mechanism involved in thyroid cancer. Thyroid cancer is increasing in incidence worldwide, and information gained from the continued issue of samples and collation of research and clinical outcome data from this project will be of value in the longer term in identifying which patients are at risk of recurrence and death from their disease .The CTB is at the forefront of human tissue banking for research, and the current proposal seeks to widen the use of samples and data stored in the bank to facilitate ongoing and future research projects, including those funded by the NIH.