Neuroimaging mechanisms of change in psychotherapy for addictive behaviors

描述（由申请人提供）：对行为改变机制（MOBC）的研究提供了一种改进成瘾行为治疗的创新方法。MOBC研究的一个重要扩展涉及使用翻译方法，该方法研究基本生物学（即，基于大脑的机制）和行为因素在作为心理治疗的结果的启动和维持积极的行为改变中相互作用。这个R13应用程序提出了一个年度会议，将与酗酒会议研究学会（RSA）一起举行，主题是“成瘾行为心理治疗变化的神经成像机制”。“会议的目标是（1）促进心理治疗和神经科学领域的研究人员之间的跨学科合作，特别是神经成像，以解决酒精治疗中基于大脑的变化机制;（2）涵盖概念、方法、从临床和神经科学的角度，探讨与MOBC研究中使用神经影像学相关的临床问题，以便为有效的协作这些目标与NIH和NIAAA的战略计划密切相关，以支持行为改变科学的变革性转化研究。我们建议召开3次年度会议，每次会议为期1.5天。每次会议将包括一整天的重点转化研究的概念和方法，然后半天与正在进行的RSA MOBC卫星，这将集中在临床问题和现实世界的应用相关的转化研究工作。多年期会议将涵盖一系列基础主题，以促进临床医生和神经科学家之间的合作，并将为与会者之间在MOBC研究方面的持续合作建立动力。在第一年，演讲将涵盖，例如，在转化研究研究设计的关键概念和方法。第二年将涵盖更高级的主题，例如与理解治疗反应和确定潜在治疗目标有关的脑回路分析方法。第三年将重点介绍实证研究结果，包括讨论进行转化研究的“现实世界”经验，以及转化研究结果在临床实践中的潜在应用。拟议的多年会议旨在推进MOBC的转化研究，这有望了解心理治疗如何改变大脑结构和功能，并促进积极行为改变的启动和维持。

DESCRIPTION (provided by applicant): Research on mechanisms of behavior change (MOBC) provides an innovative method to improve treatment for addictive behaviors. An important extension of MOBC research involves the use of translational approaches, which examine how basic biological (i.e., brain-based mechanisms) and behavioral factors interact in initiating and sustaining positive behavior change as a result of psychotherapy. This R13 application proposes an annual conference, to be held in conjunction with the Research Society on Alcoholism meeting (RSA), on the topic of "Neuroimaging mechanisms of change in psychotherapy for addictive behaviors." Conference objectives are to (1) foster cross-disciplinary collaboration among researchers in the fields of psychotherapy and neuroscience, particularly neuroimaging, to address brain-based mechanisms of change in alcohol treatment; and (2) cover conceptual, methodological, and clinical issues relevant to the use of neuroimaging in MOBC research from clinical and neuroscience perspectives in order to build a common foundation for effective collaboration. These objectives are closely aligned with NIH and NIAAA strategic plans to support transformative translational research on the science of behavior change. We propose 3 annual conferences, each 1.5 days in duration. Each conference would include a full day focused on translational research concepts and methods, followed by a half-day held in conjunction with the on-going pre-RSA MOBC satellite, which would focus on clinical issues and real-world applications relevant to translational research efforts. The multi-year conference will cover a sequenced series of foundational topics to facilitate collaboration among clinicians and neuroscientists, and will build momentum toward sustained collaboration on MOBC research among conference participants. In Year 1, presentations would cover, for example, key concepts and methods in translational research study design. Year 2 would cover more advanced topics, such as methods for analysis of brain circuits in relation to understanding treatment response and identifying potential treatment targets. Year 3 would focus on presenting empirical findings, including discussion of "real-world" experiences in conducting translational research, and potential applications of translational research findings to clinical practice. The proposed multi-year conference aims to advance translational research on MOBC, which holds promise for understanding of how psychotherapy can modify brain structure and functioning and facilitate the initiation and maintenance of positive behavioral change.